Susceptibility Patterns of Candida spp. Collected from Intensive Care Units:  A Prospective Study in 2020–2022

Teresa Nascimento; Joao Inacio Silva; Daniela Guerreiro; Patrícia Patrício; Priscila Diaz; Cristina Toscano; Isabel Faria; Helena Barroso

doi:10.3390/msf2023022045

Susceptibility Patterns of Candida spp. Collected from Intensive Care Units: A Prospective Study in 2020–2022

Teresa Nascimento
, Joao Inacio Silva
, Daniela Guerreiro
, Patrícia Patrício
, Priscila Diaz
, Cristina Toscano
, Isabel Faria
, Helena Barroso

Research output: Contribution to journal › Article › peer-review

Abstract

The frequency of Candida spp. isolates as a cause of hospital infections has risen, and in vitro antifungal susceptibility testing (AST) plays an increasingly important role in guiding therapeutic decisions. This multicenter study aimed to determine AST pattern of Candida spp. isolates from Intensive Care Unit (ICU) patients. In total, 674 patients were enrolled, and axillar/inguinal swabs were collected at admission and during the ICU stay (5th and 8th day). In vitro AST was performed on 355 Candida spp. isolates, according to the concentration gradient Etest® strip technique. The overall susceptibility rates were 100%, 99.7%, 98.3%, and 97.7% for amphotericin B, voriconazole, anidulafungin, and fluconazole, respectively. The current study demonstrates that antifungal resistance remains infrequent among Candida spp. isolates in Portugal’s ICUs.

Original language	English
Article number	45
Number of pages	3
Journal	The 6th International Congress of CiiEM&mdash;Immediate and Future Challenges to Foster One Health
Volume	22
Issue number	1
DOIs	https://doi.org/10.3390/msf2023022045
Publication status	Published - 25 Aug 2023

Keywords

Candida spp.
ICUs
Fluconazole
Voriconazole
Amphotericin B
Anidulafungin
resistance

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10.3390/msf2023022045Licence: CC BY

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Nascimento, T., Inacio Silva, J., Guerreiro, D., Patrício, P., Diaz, P., Toscano, C., Faria, I., & Barroso, H. (2023). Susceptibility Patterns of Candida spp. Collected from Intensive Care Units: A Prospective Study in 2020–2022. The 6th International Congress of CiiEM&mdash;Immediate and Future Challenges to Foster One Health, 22(1), Article 45. https://doi.org/10.3390/msf2023022045

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title = "Susceptibility Patterns of Candida spp. Collected from Intensive Care Units: A Prospective Study in 2020–2022",

abstract = "The frequency of Candida spp. isolates as a cause of hospital infections has risen, and in vitro antifungal susceptibility testing (AST) plays an increasingly important role in guiding therapeutic decisions. This multicenter study aimed to determine AST pattern of Candida spp. isolates from Intensive Care Unit (ICU) patients. In total, 674 patients were enrolled, and axillar/inguinal swabs were collected at admission and during the ICU stay (5th and 8th day). In vitro AST was performed on 355 Candida spp. isolates, according to the concentration gradient Etest{\textregistered} strip technique. The overall susceptibility rates were 100\%, 99.7\%, 98.3\%, and 97.7\% for amphotericin B, voriconazole, anidulafungin, and fluconazole, respectively. The current study demonstrates that antifungal resistance remains infrequent among Candida spp. isolates in Portugal{\textquoteright}s ICUs.",

keywords = "Candida spp., ICUs, Fluconazole, Voriconazole, Amphotericin B, Anidulafungin, resistance",

author = "Teresa Nascimento and \{Inacio Silva\}, Joao and Daniela Guerreiro and Patr{\'i}cia Patr{\'i}cio and Priscila Diaz and Cristina Toscano and Isabel Faria and Helena Barroso",

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month = aug,

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Nascimento, T, Inacio Silva, J, Guerreiro, D, Patrício, P, Diaz, P, Toscano, C, Faria, I & Barroso, H 2023, 'Susceptibility Patterns of Candida spp. Collected from Intensive Care Units: A Prospective Study in 2020–2022', The 6th International Congress of CiiEM&mdash;Immediate and Future Challenges to Foster One Health, vol. 22, no. 1, 45. https://doi.org/10.3390/msf2023022045

Susceptibility Patterns of Candida spp. Collected from Intensive Care Units: A Prospective Study in 2020–2022. / Nascimento, Teresa; Inacio Silva, Joao; Guerreiro, Daniela et al.
In: The 6th International Congress of CiiEM&mdash;Immediate and Future Challenges to Foster One Health, Vol. 22, No. 1, 45, 25.08.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Susceptibility Patterns of Candida spp. Collected from Intensive Care Units

T2 - A Prospective Study in 2020–2022

AU - Nascimento, Teresa

AU - Inacio Silva, Joao

AU - Guerreiro, Daniela

AU - Patrício, Patrícia

AU - Diaz, Priscila

AU - Toscano, Cristina

AU - Faria, Isabel

AU - Barroso, Helena

PY - 2023/8/25

Y1 - 2023/8/25

N2 - The frequency of Candida spp. isolates as a cause of hospital infections has risen, and in vitro antifungal susceptibility testing (AST) plays an increasingly important role in guiding therapeutic decisions. This multicenter study aimed to determine AST pattern of Candida spp. isolates from Intensive Care Unit (ICU) patients. In total, 674 patients were enrolled, and axillar/inguinal swabs were collected at admission and during the ICU stay (5th and 8th day). In vitro AST was performed on 355 Candida spp. isolates, according to the concentration gradient Etest® strip technique. The overall susceptibility rates were 100%, 99.7%, 98.3%, and 97.7% for amphotericin B, voriconazole, anidulafungin, and fluconazole, respectively. The current study demonstrates that antifungal resistance remains infrequent among Candida spp. isolates in Portugal’s ICUs.

AB - The frequency of Candida spp. isolates as a cause of hospital infections has risen, and in vitro antifungal susceptibility testing (AST) plays an increasingly important role in guiding therapeutic decisions. This multicenter study aimed to determine AST pattern of Candida spp. isolates from Intensive Care Unit (ICU) patients. In total, 674 patients were enrolled, and axillar/inguinal swabs were collected at admission and during the ICU stay (5th and 8th day). In vitro AST was performed on 355 Candida spp. isolates, according to the concentration gradient Etest® strip technique. The overall susceptibility rates were 100%, 99.7%, 98.3%, and 97.7% for amphotericin B, voriconazole, anidulafungin, and fluconazole, respectively. The current study demonstrates that antifungal resistance remains infrequent among Candida spp. isolates in Portugal’s ICUs.

KW - Candida spp.

KW - ICUs

KW - Fluconazole

KW - Voriconazole

KW - Amphotericin B

KW - Anidulafungin

KW - resistance

U2 - 10.3390/msf2023022045

DO - 10.3390/msf2023022045

M3 - Article

VL - 22

JO - The 6th International Congress of CiiEM&mdash;Immediate and Future Challenges to Foster One Health

JF - The 6th International Congress of CiiEM&mdash;Immediate and Future Challenges to Foster One Health

IS - 1

M1 - 45

ER -

Susceptibility Patterns of Candida spp. Collected from Intensive Care Units: A Prospective Study in 2020–2022

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Keywords

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