Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide

Dmitriy Shurpik, Olga Mostovaya, Denis Sevastyanov, Oksana Lenina, Anastasiya Sapunova, Alexandra Voloshina, Konstantin Petrov, Irina Kovyazina, Peter Cragg, Ivan Stoikov

Research output: Contribution to journalArticle

Abstract

A water-soluble pillar[5]arene, decafunctionalized with thioether and carboxylate fragments, was synthesized as a structural analogue of Sugammadex. Its ability to restore the contraction of the diaphragm muscle by encapsulating the muscle relaxant rocuronium bromide was demonstrated. Using UV-vis, NMR and fluorescence spectroscopy, it was shown that the muscle relaxant is associated with the pillar[5]arene with an association constant of 4500 M -1 and a stoichiometry of 1 : 1. The structure of the inclusion complex of the pillar[5]arene with rocuronium bromide was additionally investigated by quantum chemical methods.

Original languageEnglish
Pages (from-to)9951-9959
Number of pages9
JournalOrganic & Biomolecular Chemistry
Volume17
Issue number46
DOIs
Publication statusPublished - 7 Nov 2019

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muscle relaxants
Neuromuscular Blocking Agents
Muscle
bromides
inclusions
encapsulating
diaphragms
muscles
carboxylates
contraction
stoichiometry
Muscles
Fluorescence Spectrometry
Fluorescence spectroscopy
fragments
Sulfides
analogs
Muscle Contraction
Diaphragms
Diaphragm

Cite this

Shurpik, D., Mostovaya, O., Sevastyanov, D., Lenina, O., Sapunova, A., Voloshina, A., ... Stoikov, I. (2019). Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide. Organic & Biomolecular Chemistry, 17(46), 9951-9959. https://doi.org/10.1039/C9OB02215E
Shurpik, Dmitriy ; Mostovaya, Olga ; Sevastyanov, Denis ; Lenina, Oksana ; Sapunova, Anastasiya ; Voloshina, Alexandra ; Petrov, Konstantin ; Kovyazina, Irina ; Cragg, Peter ; Stoikov, Ivan. / Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide. In: Organic & Biomolecular Chemistry. 2019 ; Vol. 17, No. 46. pp. 9951-9959.
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Shurpik, D, Mostovaya, O, Sevastyanov, D, Lenina, O, Sapunova, A, Voloshina, A, Petrov, K, Kovyazina, I, Cragg, P & Stoikov, I 2019, 'Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide', Organic & Biomolecular Chemistry, vol. 17, no. 46, pp. 9951-9959. https://doi.org/10.1039/C9OB02215E

Supramolecular neuromuscular blocker inhibition by a pillar[5]arene through aqueous inclusion of rocuronium bromide. / Shurpik, Dmitriy ; Mostovaya, Olga; Sevastyanov, Denis; Lenina, Oksana; Sapunova, Anastasiya; Voloshina, Alexandra; Petrov, Konstantin; Kovyazina, Irina; Cragg, Peter; Stoikov, Ivan.

In: Organic & Biomolecular Chemistry, Vol. 17, No. 46, 07.11.2019, p. 9951-9959.

Research output: Contribution to journalArticle

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AU - Sevastyanov, Denis

AU - Lenina, Oksana

AU - Sapunova, Anastasiya

AU - Voloshina, Alexandra

AU - Petrov, Konstantin

AU - Kovyazina, Irina

AU - Cragg, Peter

AU - Stoikov, Ivan

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