A water-soluble pillararene, decafunctionalized with thioether and carboxylate fragments, was synthesized as a structural analogue of Sugammadex. Its ability to restore the contraction of the diaphragm muscle by encapsulating the muscle relaxant rocuronium bromide was demonstrated. Using UV-vis, NMR and fluorescence spectroscopy, it was shown that the muscle relaxant is associated with the pillararene with an association constant of 4500 M -1 and a stoichiometry of 1 : 1. The structure of the inclusion complex of the pillararene with rocuronium bromide was additionally investigated by quantum chemical methods.
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- School of Applied Sciences - Prof. in Supramolecular Chemistry
- Centre for Precision Health and Translational Medicine
- Applied Chemical Sciences Research and Enterprise Group
- Centre for Lifelong Health