The γ-ray decay of isomeric states in the even-even nucleus 128Cd has been observed. The nucleus of interest was produced both by the fragmentation of 136Xe and the fission of 238U primary beams. The level scheme was unambiguously constructed based on γγ coincidence relations in conjunction with detailed lifetime analysis employed for the first time on this nucleus. Large-scale shell-model calculations, without consideration of excitations across the N=82 shell closure, were performed and provide a consistent description of the experimental level scheme. The structure of the isomeric states and their decays exhibit coexistence of proton, neutron, and strongly mixed configurations due to πν interaction in overlapping orbitals for both proton and neutron holes.