Skin deep: the basics of human skin structure and drug penetration

Keng Wooi Ng; Wing Man Lau

doi:10.1007/978-3-662-45013-0_1

Skin deep: the basics of human skin structure and drug penetration

Keng Wooi Ng, Wing Man Lau

University of Brighton

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter

Abstract

Drug penetration and permeation through the skin are greatly influenced by the structural properties of the skin and the physicochemical properties of the drug. As such, penetration enhancement techniques largely focus on manipulating these two key factors. A great deal of research has focused on the stratum corneum, the primary skin barrier. In this chapter, we describe the structural properties of human skin, its functions, and the basic principles of drug penetration. The lipid composition and structural organisation of the stratum corneum, as well as the pathways of drug permeation, are highlighted. This chapter should provide a basic understanding of these topics and prepare the reader for advanced discussions in the specialist chapters that follow.

Original language	English
Title of host publication	Percutaneous penetration enhancers: chemical methods in penetration enhancement
Editors	N. Dragicevic, H.I. Maibach
Place of Publication	Berlin/Heidelberg
Publisher	Springer-Verlag
Pages	3-11
Number of pages	9
ISBN (Electronic)	9783662450130
ISBN (Print)	9783662450123
DOIs	https://doi.org/10.1007/978-3-662-45013-0_1
Publication status	Published - 1 Jan 2015

Keywords

Skin function
stratum corneum
lipid organisation
ceramide
permeation pathway

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AU - Lau, Wing Man

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N2 - Drug penetration and permeation through the skin are greatly influenced by the structural properties of the skin and the physicochemical properties of the drug. As such, penetration enhancement techniques largely focus on manipulating these two key factors. A great deal of research has focused on the stratum corneum, the primary skin barrier. In this chapter, we describe the structural properties of human skin, its functions, and the basic principles of drug penetration. The lipid composition and structural organisation of the stratum corneum, as well as the pathways of drug permeation, are highlighted. This chapter should provide a basic understanding of these topics and prepare the reader for advanced discussions in the specialist chapters that follow.

AB - Drug penetration and permeation through the skin are greatly influenced by the structural properties of the skin and the physicochemical properties of the drug. As such, penetration enhancement techniques largely focus on manipulating these two key factors. A great deal of research has focused on the stratum corneum, the primary skin barrier. In this chapter, we describe the structural properties of human skin, its functions, and the basic principles of drug penetration. The lipid composition and structural organisation of the stratum corneum, as well as the pathways of drug permeation, are highlighted. This chapter should provide a basic understanding of these topics and prepare the reader for advanced discussions in the specialist chapters that follow.

KW - Skin function

KW - stratum corneum

KW - lipid organisation

KW - ceramide

KW - permeation pathway

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BT - Percutaneous penetration enhancers: chemical methods in penetration enhancement

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A2 - Maibach, H.I.

PB - Springer-Verlag

CY - Berlin/Heidelberg

ER -

Skin deep: the basics of human skin structure and drug penetration

Abstract

Keywords

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