TY - JOUR
T1 - Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat
AU - Nesic, Z.
AU - Todorovic, Z.
AU - Stojanovic, R.
AU - Basta-Jovanovic, G.
AU - Radojevic-Skodric, S.
AU - Velickovic, R.
AU - Chatterjee, P.K.
AU - Thiemermann, C.
AU - Prostran, M.
PY - 2006/11
Y1 - 2006/11
N2 - The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.
AB - The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.
U2 - 10.1024/jphs.SCE06002X
DO - 10.1024/jphs.SCE06002X
M3 - Article
SN - 1347-8613
VL - 102
SP - 413
EP - 417
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 4
ER -