Abstract
The use of sequential methods in clinical trials dates back to the 1940s. With these methods, the accruing data are inspected periodically in order to assess whether the trial should be continued. Trials can be stopped when there is convincing evidence of a treatment effect or they can be stopped for futility. The use of sequential methods can reduce the numbers of patients in the trial compared with a design with a fixed sample size.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Statistics in Behavioral Science |
| Editors | Brian S. Everitt, David C. Howell |
| Place of Publication | Chichester |
| Publisher | John Wiley & Sons |
| Pages | 1819-1820 |
| Number of pages | 2 |
| Volume | 4 |
| ISBN (Electronic) | 9780470013199 |
| ISBN (Print) | 9780470860809 |
| DOIs | |
| Publication status | Published - 2005 |
Keywords
- average sample size
- clinical trial
- early stopping
- interim analysis
- stopping boundary
- test statistics
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