Abstract

The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts.Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms lls can beameliorated.
Original languageEnglish
JournalF1000 Research
Volume6
DOIs
Publication statusPublished - 25 Jul 2017

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Bibliographical note

© 2017 Faragher RG et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this

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title = "Senescence in the aging process",
abstract = "The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts.Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms lls can beameliorated.",
author = "Richard Faragher and Anne McArdle and Alison Willows and Elizabeth Ostler",
note = "{\circledC} 2017 Faragher RG et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2017",
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day = "25",
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Senescence in the aging process. / Faragher, Richard; McArdle, Anne; Willows, Alison; Ostler, Elizabeth.

In: F1000 Research, Vol. 6, 25.07.2017.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Faragher, Richard

AU - McArdle, Anne

AU - Willows, Alison

AU - Ostler, Elizabeth

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N2 - The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts.Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms lls can beameliorated.

AB - The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts.Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms lls can beameliorated.

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DO - 10.12688/f1000research.10903.1

M3 - Article

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