Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Dmitriy  Shurpik; Yulia Aleksandrova; Olga Mostovaya; Viktoriya Nazmutdinova; Regina Tazieva; Fadis Murzakhanov; Marat Gafurov; Pavel Zelenikhin; Evgenia Subakaeva; Evgenia Sokolova; Alexander  Gerasimov; Vadim Gorodov; Daut Islamov; Peter Cragg; Ivan Stoikov

doi:10.3390/nano12091604

Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Dmitriy Shurpik
, Yulia Aleksandrova
, Olga Mostovaya
, Viktoriya Nazmutdinova
, Regina Tazieva
, Fadis Murzakhanov
, Marat Gafurov
, Pavel Zelenikhin
, Evgenia Subakaeva
, Evgenia Sokolova
, Alexander Gerasimov
, Vadim Gorodov
, Daut Islamov
, Peter Cragg
, Ivan Stoikov

Research output: Contribution to journal › Article › peer-review

Abstract

Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.

Original language	English
Article number	1604
Pages (from-to)	1604
Number of pages	20
Journal	Nanomaterials
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/nano12091604
Publication status	Published - 9 May 2022

Bibliographical note

Funding Information:
Funding: The work was supported by Russian Science Foundation (№20-73-00161). Investigation of spatial structure of compounds by NMR spectroscopy was supported by the Kazan Federal University Strategic Academic Leadership Program (‘PRIORITY-2030’).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

pillar[5]arene
self-healing
moxifloxacin hydrochloride
electron spin resonance
polymer films
polythiols
antibacterial activity

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Shurpik, D., Aleksandrova, Y., Mostovaya, O., Nazmutdinova, V., Tazieva, R., Murzakhanov, F., Gafurov, M., Zelenikhin, P., Subakaeva, E., Sokolova, E., Gerasimov, A., Gorodov, V., Islamov, D., Cragg, P., & Stoikov, I. (2022). Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms. Nanomaterials, 12(9), 1604. Article 1604. https://doi.org/10.3390/nano12091604

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title = "Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms",

abstract = "Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces. ",

keywords = "pillar[5]arene, self-healing, moxifloxacin hydrochloride, electron spin resonance, polymer films, polythiols, antibacterial activity",

author = "Dmitriy Shurpik and Yulia Aleksandrova and Olga Mostovaya and Viktoriya Nazmutdinova and Regina Tazieva and Fadis Murzakhanov and Marat Gafurov and Pavel Zelenikhin and Evgenia Subakaeva and Evgenia Sokolova and Alexander Gerasimov and Vadim Gorodov and Daut Islamov and Peter Cragg and Ivan Stoikov",

note = "Funding Information: Funding: The work was supported by Russian Science Foundation (№20-73-00161). Investigation of spatial structure of compounds by NMR spectroscopy was supported by the Kazan Federal University Strategic Academic Leadership Program ({\textquoteleft}PRIORITY-2030{\textquoteright}). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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month = may,

day = "9",

doi = "10.3390/nano12091604",

language = "English",

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Shurpik, D, Aleksandrova, Y, Mostovaya, O, Nazmutdinova, V, Tazieva, R, Murzakhanov, F, Gafurov, M, Zelenikhin, P, Subakaeva, E, Sokolova, E, Gerasimov, A, Gorodov, V, Islamov, D, Cragg, P & Stoikov, I 2022, 'Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms', Nanomaterials, vol. 12, no. 9, 1604, pp. 1604. https://doi.org/10.3390/nano12091604

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T1 - Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

AU - Shurpik, Dmitriy

AU - Aleksandrova, Yulia

AU - Mostovaya, Olga

AU - Nazmutdinova, Viktoriya

AU - Tazieva, Regina

AU - Murzakhanov, Fadis

AU - Gafurov, Marat

AU - Zelenikhin, Pavel

AU - Subakaeva, Evgenia

AU - Sokolova, Evgenia

AU - Gerasimov, Alexander

AU - Gorodov, Vadim

AU - Islamov, Daut

AU - Cragg, Peter

AU - Stoikov, Ivan

N1 - Funding Information: Funding: The work was supported by Russian Science Foundation (№20-73-00161). Investigation of spatial structure of compounds by NMR spectroscopy was supported by the Kazan Federal University Strategic Academic Leadership Program (‘PRIORITY-2030’). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5/9

Y1 - 2022/5/9

N2 - Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.

AB - Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.

KW - pillar[5]arene

KW - self-healing

KW - moxifloxacin hydrochloride

KW - electron spin resonance

KW - polymer films

KW - polythiols

KW - antibacterial activity

U2 - 10.3390/nano12091604

DO - 10.3390/nano12091604

M3 - Article

VL - 12

SP - 1604

JO - Nanomaterials

JF - Nanomaterials

IS - 9

M1 - 1604

ER -

Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Abstract

Bibliographical note

Keywords

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