Polymer self-healing films containing fragments of pillararene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillararene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.
Funding: The work was supported by Russian Science Foundation (№20-73-00161). Investigation of spatial structure of compounds by NMR spectroscopy was supported by the Kazan Federal University Strategic Academic Leadership Program (‘PRIORITY-2030’).
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- moxifloxacin hydrochloride
- electron spin resonance
- polymer films
- antibacterial activity