Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Dmitriy Shurpik, Yulia Aleksandrova, Olga Mostovaya, Viktoriya Nazmutdinova, Regina Tazieva, Fadis Murzakhanov, Marat Gafurov, Pavel Zelenikhin, Evgenia Subakaeva, Evgenia Sokolova, Alexander Gerasimov, Vadim Gorodov, Daut Islamov, Peter Cragg, Ivan Stoikov

Research output: Contribution to journalArticlepeer-review


Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.
Original languageEnglish
Article number1604
Pages (from-to)1604
Number of pages20
Issue number9
Publication statusPublished - 9 May 2022

Bibliographical note

Funding Information:
Funding: The work was supported by Russian Science Foundation (№20-73-00161). Investigation of spatial structure of compounds by NMR spectroscopy was supported by the Kazan Federal University Strategic Academic Leadership Program (‘PRIORITY-2030’).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • pillar[5]arene
  • self-healing
  • moxifloxacin hydrochloride
  • electron spin resonance
  • polymer films
  • polythiols
  • antibacterial activity


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