Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms

Dmitriy Shurpik, Yulia Aleksandrova, Olga Mostovaya, Viktoriya Nazmutdinova, Regina Tazieva, Fadis Murzakhanov, Marat Gafurov, Pavel Zelenikhin, Evgenia Subakaeva, Evgenia Sokolova, Alexander Gerasimov, Vadim Gorodov, Daut Islamov, Peter Cragg, Ivan Stoikov

Research output: Contribution to journalArticlepeer-review

Abstract

Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.
Original languageEnglish
Article number1604
Number of pages20
JournalNanomaterials
Volume12
DOIs
Publication statusPublished - 9 May 2022

Keywords

  • pillar[5]arene
  • self-healing
  • moxifloxacin hydrochloride
  • electron spin resonance
  • polymer films
  • polythiols
  • antibacterial activity

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