Selenium stimulates pancreatic beta cell gene expression and enhances islet function

S.C. Campbell, A. Aldibbiat, Claire Marriott, C. Landy, T. Ali, W.F. Ferris, C.S. Butler, J.A. Shaw, Wendy Macfarlane

Research output: Contribution to journalArticle

Abstract

The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.
Original languageEnglish
Pages (from-to)2333-2337
Number of pages5
JournalFebs Letters
Volume582
Issue number15
DOIs
Publication statusPublished - 2008

Keywords

  • Beta-cell
  • Islets of Langerhans
  • Transcription
  • Selenium
  • IPF1

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    Campbell, S. C., Aldibbiat, A., Marriott, C., Landy, C., Ali, T., Ferris, W. F., Butler, C. S., Shaw, J. A., & Macfarlane, W. (2008). Selenium stimulates pancreatic beta cell gene expression and enhances islet function. Febs Letters, 582(15), 2333-2337. https://doi.org/10.1016/j.febslet.2008.05.038