Selenium stimulates pancreatic beta cell gene expression and enhances islet function

S.C. Campbell; A. Aldibbiat; Claire Marriott; C. Landy; T. Ali; W.F. Ferris; C.S. Butler; J.A. Shaw; Wendy Macfarlane

doi:10.1016/j.febslet.2008.05.038

Selenium stimulates pancreatic beta cell gene expression and enhances islet function

S.C. Campbell, A. Aldibbiat, Claire Marriott, C. Landy, T. Ali, W.F. Ferris, C.S. Butler, J.A. Shaw, Wendy Macfarlane

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.

Original language	English
Pages (from-to)	2333-2337
Number of pages	5
Journal	Febs Letters
Volume	582
Issue number	15
DOIs	https://doi.org/10.1016/j.febslet.2008.05.038
Publication status	Published - 2008

Keywords

Beta-cell
Islets of Langerhans
Transcription
Selenium
IPF1

Access to Document

10.1016/j.febslet.2008.05.038Licence: Unspecified

http://www.febsletters.org/article/S0014-5793(08)00464-X/abstractLicence: Unspecified

Cite this

@article{d25e305115dd4c9faa6884a7ff8453a1,

title = "Selenium stimulates pancreatic beta cell gene expression and enhances islet function",

abstract = "The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.",

keywords = "Beta-cell, Islets of Langerhans, Transcription, Selenium, IPF1",

author = "S.C. Campbell and A. Aldibbiat and Claire Marriott and C. Landy and T. Ali and W.F. Ferris and C.S. Butler and J.A. Shaw and Wendy Macfarlane",

year = "2008",

doi = "10.1016/j.febslet.2008.05.038",

language = "English",

volume = "582",

pages = "2333--2337",

journal = "Febs Letters",

issn = "0014-5793",

number = "15",

}

TY - JOUR

T1 - Selenium stimulates pancreatic beta cell gene expression and enhances islet function

AU - Campbell, S.C.

AU - Aldibbiat, A.

AU - Marriott, Claire

AU - Landy, C.

AU - Ali, T.

AU - Ferris, W.F.

AU - Butler, C.S.

AU - Shaw, J.A.

AU - Macfarlane, Wendy

PY - 2008

Y1 - 2008

N2 - The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.

AB - The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.

KW - Beta-cell

KW - Islets of Langerhans

KW - Transcription

KW - Selenium

KW - IPF1

U2 - 10.1016/j.febslet.2008.05.038

DO - 10.1016/j.febslet.2008.05.038

M3 - Article

SN - 0014-5793

VL - 582

SP - 2333

EP - 2337

JO - Febs Letters

JF - Febs Letters

IS - 15

ER -

Selenium stimulates pancreatic beta cell gene expression and enhances islet function

Abstract

Keywords

Access to Document

Fingerprint

Cite this