Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids

Luca S. Dobson, Graham Pattison

Research output: Contribution to journalArticle

Abstract

The Rh-catalyzed arylation of fluorinated ketones with boronic acids is reported. This efficient process allows access to fluorinated alcohols in high yields under mild conditions. Competition experiments suggest that difluoromethyl ketones are more reactive than trifluoromethyl ketones in this process, despite their decreased electronic activation, an effect we postulate to be steric in origin.

Original languageEnglish
Pages (from-to)11116-11119
Number of pages4
JournalChemical Communications
Volume52
Issue number74
DOIs
Publication statusPublished - 16 Aug 2016

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