Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups

S.M. Moghimi, A.C. Hunter

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The interaction of liposomes with blood proteins is believed to play a critical role in the clearance pharmacokinetics and tissue distribution of intravenously injected liposomes. In this article we have focused our discussion on the interaction of liposomes with key blood proteins, which include immunoglobulins, complement proteins, apolipoproteins, fetuin, von Willebrand factor, and thrombospondin, and their role in liposome recognition by professional phagocytes and nonmacrophage hepatic cells. Alternatively, macrophages as well as hepatocytes and liver endothelial cells may phagocytose/endocytose liposomes via direct recognition of phospholipid headgroups. A number of plasma membrane receptors such as lectin receptors, CD14, various classes of scavenger receptors (e.g., classes A, B, and D), Fc?RI and Fc?RII-B2 may participate in phospholipid recognition. These concepts are also discussed.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalPharmaceutical research
Volume18
Issue number1
Publication statusPublished - Jan 2001

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Liposomes
Phospholipids
Macrophages
Liver
Blood Proteins
Hepatocytes
Class A Scavenger Receptors
Mitogen Receptors
Fetuins
Thrombospondins
Cytophagocytosis
Apolipoproteins
von Willebrand Factor
Tissue Distribution
Phagocytes
Endocytosis
Immunoglobulins
Complement System Proteins
Endothelial Cells
Pharmacokinetics

Bibliographical note

The original publication is available at www.springerlink.com

Cite this

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Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups. / Moghimi, S.M.; Hunter, A.C.

In: Pharmaceutical research, Vol. 18, No. 1, 01.2001, p. 1-8.

Research output: Contribution to journalArticleResearchpeer-review

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