Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity - Implications in experimental and clinical oncology

P. Laverman, M.G. Carstens, G. Storm, S.M. Moghimi

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Intravenous injection of an endotoxin-free solution of poloxamine-908 to rats can enhance the phagocytic clearance capacity of tissue macrophages, particularly those of the liver and the spleen. Such stimulated cells were able to clear a significant portion of intravenously injected methoxypoly(ethyleneglycol)2000 liposomes (mean size of 87 nm), labelled with technetium-99m via the N-hydroxysuccinimidyl hydrazine nicotinate hydrochloride derivative of distearoyl phosphatidylethanolamine, within 4 h post administration. These liposomes, otherwise, exhibit long circulatory behaviour in control animals, with poor localization to the liver and spleen. We suggest that such technetium-99m-labelled engineered vesicles may be of aid for detection of the liver and spleen macrophages with enhanced phagocytic clearance capacity by gamma scintigraphy. Alterations in the phagocytic activity of liver and spleen macrophages is known to occur during cancer. Therefore, such diagnostic procedures may prove useful for patient selection or for monitoring the progress of treatment with long circulating nanoparticles carrying anti-cancer agents, thus minimizing damage to this important line of body’s defence cells, and are discussed.
Original languageEnglish
Pages (from-to)227-229
Number of pages3
JournalBiochimica et Biophysica Acta
Volume1526
Issue number3
Publication statusPublished - Jun 2001

Fingerprint

Medical Oncology
Liposomes
Spleen
Macrophages
hydrazine
Liver
Technetium
Behavior Control
Niacin
Endotoxins
Intravenous Injections
Radionuclide Imaging
Nanoparticles
Patient Selection
Neoplasms
Therapeutics

Keywords

  • Long circulating liposome
  • Kupffer cell
  • Macrophage stimulation
  • Poloxamine
  • Cancer drug delivery

Cite this

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title = "Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity - Implications in experimental and clinical oncology",
abstract = "Intravenous injection of an endotoxin-free solution of poloxamine-908 to rats can enhance the phagocytic clearance capacity of tissue macrophages, particularly those of the liver and the spleen. Such stimulated cells were able to clear a significant portion of intravenously injected methoxypoly(ethyleneglycol)2000 liposomes (mean size of 87 nm), labelled with technetium-99m via the N-hydroxysuccinimidyl hydrazine nicotinate hydrochloride derivative of distearoyl phosphatidylethanolamine, within 4 h post administration. These liposomes, otherwise, exhibit long circulatory behaviour in control animals, with poor localization to the liver and spleen. We suggest that such technetium-99m-labelled engineered vesicles may be of aid for detection of the liver and spleen macrophages with enhanced phagocytic clearance capacity by gamma scintigraphy. Alterations in the phagocytic activity of liver and spleen macrophages is known to occur during cancer. Therefore, such diagnostic procedures may prove useful for patient selection or for monitoring the progress of treatment with long circulating nanoparticles carrying anti-cancer agents, thus minimizing damage to this important line of body’s defence cells, and are discussed.",
keywords = "Long circulating liposome, Kupffer cell, Macrophage stimulation, Poloxamine, Cancer drug delivery",
author = "P. Laverman and M.G. Carstens and G. Storm and S.M. Moghimi",
year = "2001",
month = "6",
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pages = "227--229",
journal = "Biochimica et Biophysica Acta",
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Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity - Implications in experimental and clinical oncology. / Laverman, P.; Carstens, M.G.; Storm, G.; Moghimi, S.M.

In: Biochimica et Biophysica Acta, Vol. 1526, No. 3, 06.2001, p. 227-229.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity - Implications in experimental and clinical oncology

AU - Laverman, P.

AU - Carstens, M.G.

AU - Storm, G.

AU - Moghimi, S.M.

PY - 2001/6

Y1 - 2001/6

N2 - Intravenous injection of an endotoxin-free solution of poloxamine-908 to rats can enhance the phagocytic clearance capacity of tissue macrophages, particularly those of the liver and the spleen. Such stimulated cells were able to clear a significant portion of intravenously injected methoxypoly(ethyleneglycol)2000 liposomes (mean size of 87 nm), labelled with technetium-99m via the N-hydroxysuccinimidyl hydrazine nicotinate hydrochloride derivative of distearoyl phosphatidylethanolamine, within 4 h post administration. These liposomes, otherwise, exhibit long circulatory behaviour in control animals, with poor localization to the liver and spleen. We suggest that such technetium-99m-labelled engineered vesicles may be of aid for detection of the liver and spleen macrophages with enhanced phagocytic clearance capacity by gamma scintigraphy. Alterations in the phagocytic activity of liver and spleen macrophages is known to occur during cancer. Therefore, such diagnostic procedures may prove useful for patient selection or for monitoring the progress of treatment with long circulating nanoparticles carrying anti-cancer agents, thus minimizing damage to this important line of body’s defence cells, and are discussed.

AB - Intravenous injection of an endotoxin-free solution of poloxamine-908 to rats can enhance the phagocytic clearance capacity of tissue macrophages, particularly those of the liver and the spleen. Such stimulated cells were able to clear a significant portion of intravenously injected methoxypoly(ethyleneglycol)2000 liposomes (mean size of 87 nm), labelled with technetium-99m via the N-hydroxysuccinimidyl hydrazine nicotinate hydrochloride derivative of distearoyl phosphatidylethanolamine, within 4 h post administration. These liposomes, otherwise, exhibit long circulatory behaviour in control animals, with poor localization to the liver and spleen. We suggest that such technetium-99m-labelled engineered vesicles may be of aid for detection of the liver and spleen macrophages with enhanced phagocytic clearance capacity by gamma scintigraphy. Alterations in the phagocytic activity of liver and spleen macrophages is known to occur during cancer. Therefore, such diagnostic procedures may prove useful for patient selection or for monitoring the progress of treatment with long circulating nanoparticles carrying anti-cancer agents, thus minimizing damage to this important line of body’s defence cells, and are discussed.

KW - Long circulating liposome

KW - Kupffer cell

KW - Macrophage stimulation

KW - Poloxamine

KW - Cancer drug delivery

M3 - Article

VL - 1526

SP - 227

EP - 229

JO - Biochimica et Biophysica Acta

JF - Biochimica et Biophysica Acta

SN - 0304-4165

IS - 3

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