Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

K.D. Pavey; Stuart James; S.Elizabeth James; Lyuba Mikhalovska; Paul Tomlins; F. Paul; Sergey Mikhalovsky

doi:10.1039/b300989k

Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

K.D. Pavey, Stuart James, S.Elizabeth James, Lyuba Mikhalovska, Paul Tomlins, F. Paul, Sergey Mikhalovsky

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.

Original language	English
Pages (from-to)	654-656
Number of pages	3
Journal	Journal of Materials Chemistry
Volume	13
Issue number	4
DOIs	https://doi.org/10.1039/b300989k
Publication status	Published - 14 Nov 2003

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title = "Real-time monitoring of cellular integration within bulk soft tissue scaffold materials",

abstract = "A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.",

author = "K.D. Pavey and Stuart James and S.Elizabeth James and Lyuba Mikhalovska and Paul Tomlins and F. Paul and Sergey Mikhalovsky",

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AU - Pavey, K.D.

AU - James, Stuart

AU - James, S.Elizabeth

AU - Mikhalovska, Lyuba

AU - Tomlins, Paul

AU - Paul, F.

AU - Mikhalovsky, Sergey

PY - 2003/11/14

Y1 - 2003/11/14

N2 - A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.

AB - A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.

U2 - 10.1039/b300989k

DO - 10.1039/b300989k

M3 - Article

SN - 0959-9428

VL - 13

SP - 654

EP - 656

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 4

ER -

Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

Abstract

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