Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study

Syed Hasan Arshad, J. Bojarskas, S. Tsitoura, S. Matthews, B. Mealy, Taraneh Dean, W. Karmaus, Thomas Frischer, Joachim Kuehr, Johannes Forster

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background Sensitization to dust mites predisposes to asthma and allergic rhinitis, and prevention of this sensitization might reduce the rising prevalence of these disorders. Objective To test the effectiveness of dust mite avoidance measures on the development of sensitization to dust mites in children. Methods As part of a multicentre study (Study of Prevention of Allergy in Children of Europe), 242 children, aged 5–7 years, in three European countries (United Kingdom, Greece and Lithuania), were randomized to prophylactic group (n = 127) and control group (n = 115). At randomization these children were required to have a family history of atopy and positive skin test to an aeroallergen but not to house dust mite. Children in the prophylactic group were provided with dust mite impermeable mattress covers and advice on environmental measures to reduce exposure to dust-mite allergen. Control group children were given non-specific advice. After 12 months a standardized questionnaire was completed and skin prick tests were performed. Results Ten children in the prophylactic group and 19 in the control group were lost to follow-up. Three of 117 (2.56%) children in the prophylactic group and nine of 96 (9.38%) in the control group developed sensitization to dust mites. Logistic regression analysis confirmed an independent effect of prophylactic measures (adjusted odds ratio (OR): 0.14, 95% confidence interval (CI): 0.03–0.79, P = 0.03). Fifteen children need to be treated to prevent sensitization in one child. Conclusion Dust mite sensitization can be reduced in school age children with simple mite avoidance measures.
Original languageEnglish
Pages (from-to)843-849
Number of pages7
JournalClinical and Experimental Allergy
Volume32
Issue number6
Publication statusPublished - 30 May 2002

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Dermatophagoides Antigens
Mites
Dust
Control Groups
Skin Tests
Lithuania
Pyroglyphidae
Lost to Follow-Up
Greece
Random Allocation
Allergens
Multicenter Studies
Hypersensitivity
Asthma
Logistic Models

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Arshad, S. H., Bojarskas, J., Tsitoura, S., Matthews, S., Mealy, B., Dean, T., ... Forster, J. (2002). Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study. Clinical and Experimental Allergy, 32(6), 843-849.
Arshad, Syed Hasan ; Bojarskas, J. ; Tsitoura, S. ; Matthews, S. ; Mealy, B. ; Dean, Taraneh ; Karmaus, W. ; Frischer, Thomas ; Kuehr, Joachim ; Forster, Johannes. / Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study. In: Clinical and Experimental Allergy. 2002 ; Vol. 32, No. 6. pp. 843-849.
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abstract = "Background Sensitization to dust mites predisposes to asthma and allergic rhinitis, and prevention of this sensitization might reduce the rising prevalence of these disorders. Objective To test the effectiveness of dust mite avoidance measures on the development of sensitization to dust mites in children. Methods As part of a multicentre study (Study of Prevention of Allergy in Children of Europe), 242 children, aged 5–7 years, in three European countries (United Kingdom, Greece and Lithuania), were randomized to prophylactic group (n = 127) and control group (n = 115). At randomization these children were required to have a family history of atopy and positive skin test to an aeroallergen but not to house dust mite. Children in the prophylactic group were provided with dust mite impermeable mattress covers and advice on environmental measures to reduce exposure to dust-mite allergen. Control group children were given non-specific advice. After 12 months a standardized questionnaire was completed and skin prick tests were performed. Results Ten children in the prophylactic group and 19 in the control group were lost to follow-up. Three of 117 (2.56{\%}) children in the prophylactic group and nine of 96 (9.38{\%}) in the control group developed sensitization to dust mites. Logistic regression analysis confirmed an independent effect of prophylactic measures (adjusted odds ratio (OR): 0.14, 95{\%} confidence interval (CI): 0.03–0.79, P = 0.03). Fifteen children need to be treated to prevent sensitization in one child. Conclusion Dust mite sensitization can be reduced in school age children with simple mite avoidance measures.",
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Arshad, SH, Bojarskas, J, Tsitoura, S, Matthews, S, Mealy, B, Dean, T, Karmaus, W, Frischer, T, Kuehr, J & Forster, J 2002, 'Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study', Clinical and Experimental Allergy, vol. 32, no. 6, pp. 843-849.

Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study. / Arshad, Syed Hasan; Bojarskas, J.; Tsitoura, S.; Matthews, S.; Mealy, B.; Dean, Taraneh; Karmaus, W.; Frischer, Thomas; Kuehr, Joachim; Forster, Johannes.

In: Clinical and Experimental Allergy, Vol. 32, No. 6, 30.05.2002, p. 843-849.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study

AU - Arshad, Syed Hasan

AU - Bojarskas, J.

AU - Tsitoura, S.

AU - Matthews, S.

AU - Mealy, B.

AU - Dean, Taraneh

AU - Karmaus, W.

AU - Frischer, Thomas

AU - Kuehr, Joachim

AU - Forster, Johannes

PY - 2002/5/30

Y1 - 2002/5/30

N2 - Background Sensitization to dust mites predisposes to asthma and allergic rhinitis, and prevention of this sensitization might reduce the rising prevalence of these disorders. Objective To test the effectiveness of dust mite avoidance measures on the development of sensitization to dust mites in children. Methods As part of a multicentre study (Study of Prevention of Allergy in Children of Europe), 242 children, aged 5–7 years, in three European countries (United Kingdom, Greece and Lithuania), were randomized to prophylactic group (n = 127) and control group (n = 115). At randomization these children were required to have a family history of atopy and positive skin test to an aeroallergen but not to house dust mite. Children in the prophylactic group were provided with dust mite impermeable mattress covers and advice on environmental measures to reduce exposure to dust-mite allergen. Control group children were given non-specific advice. After 12 months a standardized questionnaire was completed and skin prick tests were performed. Results Ten children in the prophylactic group and 19 in the control group were lost to follow-up. Three of 117 (2.56%) children in the prophylactic group and nine of 96 (9.38%) in the control group developed sensitization to dust mites. Logistic regression analysis confirmed an independent effect of prophylactic measures (adjusted odds ratio (OR): 0.14, 95% confidence interval (CI): 0.03–0.79, P = 0.03). Fifteen children need to be treated to prevent sensitization in one child. Conclusion Dust mite sensitization can be reduced in school age children with simple mite avoidance measures.

AB - Background Sensitization to dust mites predisposes to asthma and allergic rhinitis, and prevention of this sensitization might reduce the rising prevalence of these disorders. Objective To test the effectiveness of dust mite avoidance measures on the development of sensitization to dust mites in children. Methods As part of a multicentre study (Study of Prevention of Allergy in Children of Europe), 242 children, aged 5–7 years, in three European countries (United Kingdom, Greece and Lithuania), were randomized to prophylactic group (n = 127) and control group (n = 115). At randomization these children were required to have a family history of atopy and positive skin test to an aeroallergen but not to house dust mite. Children in the prophylactic group were provided with dust mite impermeable mattress covers and advice on environmental measures to reduce exposure to dust-mite allergen. Control group children were given non-specific advice. After 12 months a standardized questionnaire was completed and skin prick tests were performed. Results Ten children in the prophylactic group and 19 in the control group were lost to follow-up. Three of 117 (2.56%) children in the prophylactic group and nine of 96 (9.38%) in the control group developed sensitization to dust mites. Logistic regression analysis confirmed an independent effect of prophylactic measures (adjusted odds ratio (OR): 0.14, 95% confidence interval (CI): 0.03–0.79, P = 0.03). Fifteen children need to be treated to prevent sensitization in one child. Conclusion Dust mite sensitization can be reduced in school age children with simple mite avoidance measures.

M3 - Article

VL - 32

SP - 843

EP - 849

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 6

ER -