Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life

C. Venter, Veeresh Patil, Jane Grundy, Gillian Glasbey, Roger Twiselton, Syed Hasan Arshad, Taraneh Dean

Research output: Contribution to journalArticle

Abstract

Background - Prevalence, incidence and natural history of food hypersensitivity (FHS) and its trends in an unselected cohort of older children are unclear.Methods - A birth cohort born on the Isle of Wight (UK) between 2001 and 2002 was followed up prospectively. Children were clinically examined and skin prick tested at set times and invited for food challenges when indicated. At 10 years of age, children were also invited for a blood test.Results - A total of 969 children were recruited at 12 weeks of pregnancy, and 92.9%, 88.5%, 91.6% and 85.3% were assessed at 1, 2, 3 and 10 years. Prevalence of sensitization to any allergen over 10 years was 186 of 969 (19.2%; 95% CI: 16.84–21.8) and 108 of 969 (11.2%; 95% CI: 9.31–13.29) children were sensitized to at least one predefined food allergen. Excluding wheat (due to cross-reactivity with pollen), 40 of 969 (4.1%; 95% CI: 3.19–5.32) children were sensitized to a predefined food allergen. Using food challenges and/or a good clinical history, the cumulative incidence of food hypersensitivity (FHS) in the first decade of life was 64 of 947 (6.8%, 95% CI: 5.2–8.4), while the prevalence of FHS at 10 years was 30 of 827 (3.6%, 95% CI: 2.54–5.15). The vast majority, 25 of 827 (3.0%, 95% CI: 1.8–4.2), suffered from IgE-mediated food allergy, while 5 of 827 (0.6%, 95% CI: 0.07–1.3) had non-IgE-mediated food allergy/food intolerance.Conclusions - By the age of 10 years, 6.8% of children suffered from FHS based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed FHS.
Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalPediatric Allergy and Immunology
Volume27
Issue number5
DOIs
Publication statusPublished - 6 May 2016

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Food Hypersensitivity
Food
Incidence
Allergens
Hematologic Tests
Pollen
Immunoglobulin E
Triticum
Parturition
Pregnancy
Skin

Bibliographical note

This is the peer reviewed version of the following article: Venter C, Patil V, Grundy J, Glasbey G, Twiselton R, Arshad SH, Dean T. Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. Pediatr Allergy Immunol 2016: 27: 452–458, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/pai.12564/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Cite this

Venter, C. ; Patil, Veeresh ; Grundy, Jane ; Glasbey, Gillian ; Twiselton, Roger ; Arshad, Syed Hasan ; Dean, Taraneh. / Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. In: Pediatric Allergy and Immunology. 2016 ; Vol. 27, No. 5. pp. 452-458.
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abstract = "Background - Prevalence, incidence and natural history of food hypersensitivity (FHS) and its trends in an unselected cohort of older children are unclear.Methods - A birth cohort born on the Isle of Wight (UK) between 2001 and 2002 was followed up prospectively. Children were clinically examined and skin prick tested at set times and invited for food challenges when indicated. At 10 years of age, children were also invited for a blood test.Results - A total of 969 children were recruited at 12 weeks of pregnancy, and 92.9{\%}, 88.5{\%}, 91.6{\%} and 85.3{\%} were assessed at 1, 2, 3 and 10 years. Prevalence of sensitization to any allergen over 10 years was 186 of 969 (19.2{\%}; 95{\%} CI: 16.84–21.8) and 108 of 969 (11.2{\%}; 95{\%} CI: 9.31–13.29) children were sensitized to at least one predefined food allergen. Excluding wheat (due to cross-reactivity with pollen), 40 of 969 (4.1{\%}; 95{\%} CI: 3.19–5.32) children were sensitized to a predefined food allergen. Using food challenges and/or a good clinical history, the cumulative incidence of food hypersensitivity (FHS) in the first decade of life was 64 of 947 (6.8{\%}, 95{\%} CI: 5.2–8.4), while the prevalence of FHS at 10 years was 30 of 827 (3.6{\%}, 95{\%} CI: 2.54–5.15). The vast majority, 25 of 827 (3.0{\%}, 95{\%} CI: 1.8–4.2), suffered from IgE-mediated food allergy, while 5 of 827 (0.6{\%}, 95{\%} CI: 0.07–1.3) had non-IgE-mediated food allergy/food intolerance.Conclusions - By the age of 10 years, 6.8{\%} of children suffered from FHS based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed FHS.",
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Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. / Venter, C.; Patil, Veeresh; Grundy, Jane; Glasbey, Gillian; Twiselton, Roger; Arshad, Syed Hasan; Dean, Taraneh.

In: Pediatric Allergy and Immunology, Vol. 27, No. 5, 06.05.2016, p. 452-458.

Research output: Contribution to journalArticle

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T1 - Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life

AU - Venter, C.

AU - Patil, Veeresh

AU - Grundy, Jane

AU - Glasbey, Gillian

AU - Twiselton, Roger

AU - Arshad, Syed Hasan

AU - Dean, Taraneh

N1 - This is the peer reviewed version of the following article: Venter C, Patil V, Grundy J, Glasbey G, Twiselton R, Arshad SH, Dean T. Prevalence and cumulative incidence of food hyper-sensitivity in the first 10 years of life. Pediatr Allergy Immunol 2016: 27: 452–458, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/pai.12564/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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N2 - Background - Prevalence, incidence and natural history of food hypersensitivity (FHS) and its trends in an unselected cohort of older children are unclear.Methods - A birth cohort born on the Isle of Wight (UK) between 2001 and 2002 was followed up prospectively. Children were clinically examined and skin prick tested at set times and invited for food challenges when indicated. At 10 years of age, children were also invited for a blood test.Results - A total of 969 children were recruited at 12 weeks of pregnancy, and 92.9%, 88.5%, 91.6% and 85.3% were assessed at 1, 2, 3 and 10 years. Prevalence of sensitization to any allergen over 10 years was 186 of 969 (19.2%; 95% CI: 16.84–21.8) and 108 of 969 (11.2%; 95% CI: 9.31–13.29) children were sensitized to at least one predefined food allergen. Excluding wheat (due to cross-reactivity with pollen), 40 of 969 (4.1%; 95% CI: 3.19–5.32) children were sensitized to a predefined food allergen. Using food challenges and/or a good clinical history, the cumulative incidence of food hypersensitivity (FHS) in the first decade of life was 64 of 947 (6.8%, 95% CI: 5.2–8.4), while the prevalence of FHS at 10 years was 30 of 827 (3.6%, 95% CI: 2.54–5.15). The vast majority, 25 of 827 (3.0%, 95% CI: 1.8–4.2), suffered from IgE-mediated food allergy, while 5 of 827 (0.6%, 95% CI: 0.07–1.3) had non-IgE-mediated food allergy/food intolerance.Conclusions - By the age of 10 years, 6.8% of children suffered from FHS based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed FHS.

AB - Background - Prevalence, incidence and natural history of food hypersensitivity (FHS) and its trends in an unselected cohort of older children are unclear.Methods - A birth cohort born on the Isle of Wight (UK) between 2001 and 2002 was followed up prospectively. Children were clinically examined and skin prick tested at set times and invited for food challenges when indicated. At 10 years of age, children were also invited for a blood test.Results - A total of 969 children were recruited at 12 weeks of pregnancy, and 92.9%, 88.5%, 91.6% and 85.3% were assessed at 1, 2, 3 and 10 years. Prevalence of sensitization to any allergen over 10 years was 186 of 969 (19.2%; 95% CI: 16.84–21.8) and 108 of 969 (11.2%; 95% CI: 9.31–13.29) children were sensitized to at least one predefined food allergen. Excluding wheat (due to cross-reactivity with pollen), 40 of 969 (4.1%; 95% CI: 3.19–5.32) children were sensitized to a predefined food allergen. Using food challenges and/or a good clinical history, the cumulative incidence of food hypersensitivity (FHS) in the first decade of life was 64 of 947 (6.8%, 95% CI: 5.2–8.4), while the prevalence of FHS at 10 years was 30 of 827 (3.6%, 95% CI: 2.54–5.15). The vast majority, 25 of 827 (3.0%, 95% CI: 1.8–4.2), suffered from IgE-mediated food allergy, while 5 of 827 (0.6%, 95% CI: 0.07–1.3) had non-IgE-mediated food allergy/food intolerance.Conclusions - By the age of 10 years, 6.8% of children suffered from FHS based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed FHS.

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JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

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