Post marathon cardiac troponin T is associated with relative exercise intensity

Alan Richardson, Tod Leckie, Emily Watkins, Daniel Fitzpatrick, Rob Galloway, Rachael Grimaldi, Polly Baker

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives: This study aimed to investigate whether measures of cardiopulmonary fitness and rela-tive exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a roadmarathon.Methods: Fifty-two marathon runners (age 39 ± 11 years, body mass 76.2 ± 12.9 kg, height 1.74 ± 0.09 m)attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Runningeconomy at 10 km h-1(RE10) and race pace (RERP), ventilatory threshold (VT) and VO2max tests werecompleted. CTnT was measured within 48 h prior to the marathon and within 10 min of completing themarathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon.Results: Runners demonstrated a significant increase in cTnT over the marathon (pre-race5.60 ± 3.27 ng L-1, post-race 74.52 ± 30.39 ng L-1, p < 0.001). Markers of endurance performancesuch as running economy (10 km h-1223 ± 18 ml kg-1km-1; race pace 225 ± 22 ml kg-1km-1), VT(38.5 ± 6.4 ml kg-1min-1) and˙VO2max (50.9 ± 7.7 ml kg-1min-1) were not associated with post-racecTnT. Runners exercise intensity correlated with post-race cTnT (mean HR %VT 104 ± 5%, r = 0.50; peakHR %VT 118 ± 8%, r = 0.68; peak HR %˙VO2max 96 ± 6, r = 0.60, p < 0.05) and was different between the low,medium and high cTnT groups (p < 0.05).Conclusions: CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related toexercise intensity relative to ventilatory threshold and˙VO2max, but not individuals' absolute cardiopul-monary fitness, training state or running history.
Original languageEnglish
JournalJournal of Science and Medicine in Sport
DOIs
Publication statusPublished - 23 Feb 2018

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Troponin T
Exercise
Heart Rate
Running

Bibliographical note

© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

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Richardson, Alan ; Leckie, Tod ; Watkins, Emily ; Fitzpatrick, Daniel ; Galloway, Rob ; Grimaldi, Rachael ; Baker, Polly. / Post marathon cardiac troponin T is associated with relative exercise intensity. In: Journal of Science and Medicine in Sport. 2018.
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title = "Post marathon cardiac troponin T is associated with relative exercise intensity",
abstract = "Objectives: This study aimed to investigate whether measures of cardiopulmonary fitness and rela-tive exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a roadmarathon.Methods: Fifty-two marathon runners (age 39 ± 11 years, body mass 76.2 ± 12.9 kg, height 1.74 ± 0.09 m)attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Runningeconomy at 10 km h-1(RE10) and race pace (RERP), ventilatory threshold (VT) and VO2max tests werecompleted. CTnT was measured within 48 h prior to the marathon and within 10 min of completing themarathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon.Results: Runners demonstrated a significant increase in cTnT over the marathon (pre-race5.60 ± 3.27 ng L-1, post-race 74.52 ± 30.39 ng L-1, p < 0.001). Markers of endurance performancesuch as running economy (10 km h-1223 ± 18 ml kg-1km-1; race pace 225 ± 22 ml kg-1km-1), VT(38.5 ± 6.4 ml kg-1min-1) and˙VO2max (50.9 ± 7.7 ml kg-1min-1) were not associated with post-racecTnT. Runners exercise intensity correlated with post-race cTnT (mean HR {\%}VT 104 ± 5{\%}, r = 0.50; peakHR {\%}VT 118 ± 8{\%}, r = 0.68; peak HR {\%}˙VO2max 96 ± 6, r = 0.60, p < 0.05) and was different between the low,medium and high cTnT groups (p < 0.05).Conclusions: CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related toexercise intensity relative to ventilatory threshold and˙VO2max, but not individuals' absolute cardiopul-monary fitness, training state or running history.",
author = "Alan Richardson and Tod Leckie and Emily Watkins and Daniel Fitzpatrick and Rob Galloway and Rachael Grimaldi and Polly Baker",
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Post marathon cardiac troponin T is associated with relative exercise intensity. / Richardson, Alan; Leckie, Tod; Watkins, Emily; Fitzpatrick, Daniel; Galloway, Rob; Grimaldi, Rachael; Baker, Polly.

In: Journal of Science and Medicine in Sport, 23.02.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Post marathon cardiac troponin T is associated with relative exercise intensity

AU - Richardson, Alan

AU - Leckie, Tod

AU - Watkins, Emily

AU - Fitzpatrick, Daniel

AU - Galloway, Rob

AU - Grimaldi, Rachael

AU - Baker, Polly

N1 - © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2018/2/23

Y1 - 2018/2/23

N2 - Objectives: This study aimed to investigate whether measures of cardiopulmonary fitness and rela-tive exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a roadmarathon.Methods: Fifty-two marathon runners (age 39 ± 11 years, body mass 76.2 ± 12.9 kg, height 1.74 ± 0.09 m)attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Runningeconomy at 10 km h-1(RE10) and race pace (RERP), ventilatory threshold (VT) and VO2max tests werecompleted. CTnT was measured within 48 h prior to the marathon and within 10 min of completing themarathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon.Results: Runners demonstrated a significant increase in cTnT over the marathon (pre-race5.60 ± 3.27 ng L-1, post-race 74.52 ± 30.39 ng L-1, p < 0.001). Markers of endurance performancesuch as running economy (10 km h-1223 ± 18 ml kg-1km-1; race pace 225 ± 22 ml kg-1km-1), VT(38.5 ± 6.4 ml kg-1min-1) and˙VO2max (50.9 ± 7.7 ml kg-1min-1) were not associated with post-racecTnT. Runners exercise intensity correlated with post-race cTnT (mean HR %VT 104 ± 5%, r = 0.50; peakHR %VT 118 ± 8%, r = 0.68; peak HR %˙VO2max 96 ± 6, r = 0.60, p < 0.05) and was different between the low,medium and high cTnT groups (p < 0.05).Conclusions: CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related toexercise intensity relative to ventilatory threshold and˙VO2max, but not individuals' absolute cardiopul-monary fitness, training state or running history.

AB - Objectives: This study aimed to investigate whether measures of cardiopulmonary fitness and rela-tive exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a roadmarathon.Methods: Fifty-two marathon runners (age 39 ± 11 years, body mass 76.2 ± 12.9 kg, height 1.74 ± 0.09 m)attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Runningeconomy at 10 km h-1(RE10) and race pace (RERP), ventilatory threshold (VT) and VO2max tests werecompleted. CTnT was measured within 48 h prior to the marathon and within 10 min of completing themarathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon.Results: Runners demonstrated a significant increase in cTnT over the marathon (pre-race5.60 ± 3.27 ng L-1, post-race 74.52 ± 30.39 ng L-1, p < 0.001). Markers of endurance performancesuch as running economy (10 km h-1223 ± 18 ml kg-1km-1; race pace 225 ± 22 ml kg-1km-1), VT(38.5 ± 6.4 ml kg-1min-1) and˙VO2max (50.9 ± 7.7 ml kg-1min-1) were not associated with post-racecTnT. Runners exercise intensity correlated with post-race cTnT (mean HR %VT 104 ± 5%, r = 0.50; peakHR %VT 118 ± 8%, r = 0.68; peak HR %˙VO2max 96 ± 6, r = 0.60, p < 0.05) and was different between the low,medium and high cTnT groups (p < 0.05).Conclusions: CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related toexercise intensity relative to ventilatory threshold and˙VO2max, but not individuals' absolute cardiopul-monary fitness, training state or running history.

U2 - 10.1016/j.jsams.2018.02.005

DO - 10.1016/j.jsams.2018.02.005

M3 - Article

JO - Journal of Science and Medicine in Sport

JF - Journal of Science and Medicine in Sport

SN - 1440-2440

ER -