Polyurethane/Poly(hydroxyethyl methacrylate) semi-Interpenetrating polymer networks for biomedical applications

B.L.V. Karabanova, Andrew Lloyd, Sergey Mikhalovsky, M. Helias, Gary Phillips, S.F. Rose, Lyuba Mikhalovska, G. Boiteux, L.M. Sergeeva, E.D. Lutsyk, A. Svyatyna

Research output: Contribution to journalArticle

Abstract

The thermodynamic miscibility, morphology, phase distribution, mechanical properties, surface properties, water sorption, bacterial adhesion and cytotoxicity of semi-interpenetrating polymer networks (semi-IPNs) based on crosslinked polyurethane (PU) and poly(hydroxyethylmethacrylate) (PHEMA) were studied to give an insight into their structure and properties. The free energies of mixing of the two polymers in semi-IPNs have been determined and it was shown that the values are positive and depend on the amount of PHEMA. This demonstrates that the components are immiscible, the extent of which is dependent upon variations in composition. The morphology of the semi-IPNs was analyzed with scanning electron microscopy and tapping mode atomic force microscopy (TMAFM). The micrographs of the semi-IPNs and TMAFM phase images indicated that distinct phase separation at the nanometer scale is observed. The mechanical properties reflect the changes in structure of semi-IPNs with composition. The stress at break increases from 3.4 MPa to 23.9 MPa, and the Young’s modulus from 12.7 MPa up to 658.5 MPa with increasing amounts of PHEMA, but strain at break has a maximum at 40.4% PHEMA. The bacterial adhesion and cytotoxicity data suggest that semi-IPNs with PHEMA content above 22% may be used for biomedical material applications.
Original languageEnglish
Pages (from-to)1283-1296
Number of pages14
JournalJournal of Material Science: Materials in Medicine
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Interpenetrating polymer networks
Polyurethanes
Cytotoxicity
Atomic force microscopy
Adhesion
Mechanical properties
Chemical analysis
Phase separation
Free energy
Surface properties
hydroxyethyl methacrylate
Sorption
Polymers
Solubility
Elastic moduli
Thermodynamics
Scanning electron microscopy
Water

Cite this

Karabanova, B.L.V. ; Lloyd, Andrew ; Mikhalovsky, Sergey ; Helias, M. ; Phillips, Gary ; Rose, S.F. ; Mikhalovska, Lyuba ; Boiteux, G. ; Sergeeva, L.M. ; Lutsyk, E.D. ; Svyatyna, A. / Polyurethane/Poly(hydroxyethyl methacrylate) semi-Interpenetrating polymer networks for biomedical applications. In: Journal of Material Science: Materials in Medicine. 2006 ; Vol. 17, No. 12. pp. 1283-1296.
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Karabanova, BLV, Lloyd, A, Mikhalovsky, S, Helias, M, Phillips, G, Rose, SF, Mikhalovska, L, Boiteux, G, Sergeeva, LM, Lutsyk, ED & Svyatyna, A 2006, 'Polyurethane/Poly(hydroxyethyl methacrylate) semi-Interpenetrating polymer networks for biomedical applications', Journal of Material Science: Materials in Medicine, vol. 17, no. 12, pp. 1283-1296. https://doi.org/10.1007/s10856-006-0603-y

Polyurethane/Poly(hydroxyethyl methacrylate) semi-Interpenetrating polymer networks for biomedical applications. / Karabanova, B.L.V.; Lloyd, Andrew; Mikhalovsky, Sergey; Helias, M.; Phillips, Gary; Rose, S.F.; Mikhalovska, Lyuba; Boiteux, G.; Sergeeva, L.M.; Lutsyk, E.D.; Svyatyna, A.

In: Journal of Material Science: Materials in Medicine, Vol. 17, No. 12, 12.2006, p. 1283-1296.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polyurethane/Poly(hydroxyethyl methacrylate) semi-Interpenetrating polymer networks for biomedical applications

AU - Karabanova, B.L.V.

AU - Lloyd, Andrew

AU - Mikhalovsky, Sergey

AU - Helias, M.

AU - Phillips, Gary

AU - Rose, S.F.

AU - Mikhalovska, Lyuba

AU - Boiteux, G.

AU - Sergeeva, L.M.

AU - Lutsyk, E.D.

AU - Svyatyna, A.

PY - 2006/12

Y1 - 2006/12

N2 - The thermodynamic miscibility, morphology, phase distribution, mechanical properties, surface properties, water sorption, bacterial adhesion and cytotoxicity of semi-interpenetrating polymer networks (semi-IPNs) based on crosslinked polyurethane (PU) and poly(hydroxyethylmethacrylate) (PHEMA) were studied to give an insight into their structure and properties. The free energies of mixing of the two polymers in semi-IPNs have been determined and it was shown that the values are positive and depend on the amount of PHEMA. This demonstrates that the components are immiscible, the extent of which is dependent upon variations in composition. The morphology of the semi-IPNs was analyzed with scanning electron microscopy and tapping mode atomic force microscopy (TMAFM). The micrographs of the semi-IPNs and TMAFM phase images indicated that distinct phase separation at the nanometer scale is observed. The mechanical properties reflect the changes in structure of semi-IPNs with composition. The stress at break increases from 3.4 MPa to 23.9 MPa, and the Young’s modulus from 12.7 MPa up to 658.5 MPa with increasing amounts of PHEMA, but strain at break has a maximum at 40.4% PHEMA. The bacterial adhesion and cytotoxicity data suggest that semi-IPNs with PHEMA content above 22% may be used for biomedical material applications.

AB - The thermodynamic miscibility, morphology, phase distribution, mechanical properties, surface properties, water sorption, bacterial adhesion and cytotoxicity of semi-interpenetrating polymer networks (semi-IPNs) based on crosslinked polyurethane (PU) and poly(hydroxyethylmethacrylate) (PHEMA) were studied to give an insight into their structure and properties. The free energies of mixing of the two polymers in semi-IPNs have been determined and it was shown that the values are positive and depend on the amount of PHEMA. This demonstrates that the components are immiscible, the extent of which is dependent upon variations in composition. The morphology of the semi-IPNs was analyzed with scanning electron microscopy and tapping mode atomic force microscopy (TMAFM). The micrographs of the semi-IPNs and TMAFM phase images indicated that distinct phase separation at the nanometer scale is observed. The mechanical properties reflect the changes in structure of semi-IPNs with composition. The stress at break increases from 3.4 MPa to 23.9 MPa, and the Young’s modulus from 12.7 MPa up to 658.5 MPa with increasing amounts of PHEMA, but strain at break has a maximum at 40.4% PHEMA. The bacterial adhesion and cytotoxicity data suggest that semi-IPNs with PHEMA content above 22% may be used for biomedical material applications.

U2 - 10.1007/s10856-006-0603-y

DO - 10.1007/s10856-006-0603-y

M3 - Article

VL - 17

SP - 1283

EP - 1296

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 1573-4838

IS - 12

ER -