Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A.C. Hunter; Jacqueline Elsom; Peter P. Wibroe; S.M. Moghimi

doi:10.1016/j.maturitas.2012.05.014

Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A.C. Hunter, Jacqueline Elsom, Peter P. Wibroe, S.M. Moghimi

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

Original language	English
Pages (from-to)	5-18
Number of pages	14
Journal	Maturitas
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.maturitas.2012.05.014
Publication status	Published - 17 Jun 2012

Keywords

Oral drug delivery
Polymer
Gastrointestinal tract
Nanoparticle
Microparticle
Peyers's patch
Enterocyte
Complement

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title = "Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective",

abstract = "The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.",

keywords = "Oral drug delivery, Polymer, Gastrointestinal tract, Nanoparticle, Microparticle, Peyers's patch, Enterocyte, Complement",

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AU - Hunter, A.C.

AU - Elsom, Jacqueline

AU - Wibroe, Peter P.

AU - Moghimi, S.M.

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AB - The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

KW - Oral drug delivery

KW - Polymer

KW - Gastrointestinal tract

KW - Nanoparticle

KW - Microparticle

KW - Peyers's patch

KW - Enterocyte

KW - Complement

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JO - Maturitas

JF - Maturitas

IS - 1

ER -

Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

Abstract

Keywords

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