Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A.C. Hunter, Jacqueline Elsom, Peter P. Wibroe, S.M. Moghimi

Research output: Contribution to journalArticle

Abstract

The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.
Original languageEnglish
Pages (from-to)5-18
Number of pages14
JournalMaturitas
Volume73
Issue number1
DOIs
Publication statusPublished - 17 Jun 2012

Keywords

  • Oral drug delivery
  • Polymer
  • Gastrointestinal tract
  • Nanoparticle
  • Microparticle
  • Peyers's patch
  • Enterocyte
  • Complement

Fingerprint Dive into the research topics of 'Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective'. Together they form a unique fingerprint.

  • Cite this