Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, Ian Wilson, John A. Christopher, David D. Miller, Paul W. Smith, Antonio Vong

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Original languageEnglish
Title of host publicationFluorine in Medicinal Chemistry and Chemical Biology
PublisherJohn Wiley & Sons, Ltd
Pages291-311
Number of pages21
ISBN (Print)9781405167208
DOIs
Publication statusPublished - 21 Apr 2009

Keywords

  • Advances in technology and high-throughput screening (HTS)
  • Biologically active heteroaromatic systems
  • Lipinski parameters (RO5) for predicting "drug-likeness" of potential molecular targets
  • Perfluorinated heteroaromatic systems as scaffolds for drug discovery
  • Perfluorinated heterocycles as core scaffolds
  • Privileged structures, core scaffolds and RAS in drug discovery process
  • Synthesis of 2-pyridone systems from pentafluoropyridine
  • Tetrafluoropyrimidine as a core scaffold

Cite this

Armstrong, D., Cartwright, M. W., Parks, E. L., Pattison, G., Sandford, G., Slater, R., ... Vong, A. (2009). Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. In Fluorine in Medicinal Chemistry and Chemical Biology (pp. 291-311). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781444312096.ch11
Armstrong, David ; Cartwright, Matthew W. ; Parks, Emma L. ; Pattison, Graham ; Sandford, Graham ; Slater, Rachel ; Wilson, Ian ; Christopher, John A. ; Miller, David D. ; Smith, Paul W. ; Vong, Antonio. / Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. Fluorine in Medicinal Chemistry and Chemical Biology. John Wiley & Sons, Ltd, 2009. pp. 291-311
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author = "David Armstrong and Cartwright, {Matthew W.} and Parks, {Emma L.} and Graham Pattison and Graham Sandford and Rachel Slater and Ian Wilson and Christopher, {John A.} and Miller, {David D.} and Smith, {Paul W.} and Antonio Vong",
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Armstrong, D, Cartwright, MW, Parks, EL, Pattison, G, Sandford, G, Slater, R, Wilson, I, Christopher, JA, Miller, DD, Smith, PW & Vong, A 2009, Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. in Fluorine in Medicinal Chemistry and Chemical Biology. John Wiley & Sons, Ltd, pp. 291-311. https://doi.org/10.1002/9781444312096.ch11

Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. / Armstrong, David; Cartwright, Matthew W.; Parks, Emma L.; Pattison, Graham; Sandford, Graham; Slater, Rachel; Wilson, Ian; Christopher, John A.; Miller, David D.; Smith, Paul W.; Vong, Antonio.

Fluorine in Medicinal Chemistry and Chemical Biology. John Wiley & Sons, Ltd, 2009. p. 291-311.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

TY - CHAP

T1 - Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

AU - Armstrong, David

AU - Cartwright, Matthew W.

AU - Parks, Emma L.

AU - Pattison, Graham

AU - Sandford, Graham

AU - Slater, Rachel

AU - Wilson, Ian

AU - Christopher, John A.

AU - Miller, David D.

AU - Smith, Paul W.

AU - Vong, Antonio

PY - 2009/4/21

Y1 - 2009/4/21

KW - Advances in technology and high-throughput screening (HTS)

KW - Biologically active heteroaromatic systems

KW - Lipinski parameters (RO5) for predicting "drug-likeness" of potential molecular targets

KW - Perfluorinated heteroaromatic systems as scaffolds for drug discovery

KW - Perfluorinated heterocycles as core scaffolds

KW - Privileged structures, core scaffolds and RAS in drug discovery process

KW - Synthesis of 2-pyridone systems from pentafluoropyridine

KW - Tetrafluoropyrimidine as a core scaffold

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U2 - 10.1002/9781444312096.ch11

DO - 10.1002/9781444312096.ch11

M3 - Chapter

AN - SCOPUS:84889333160

SN - 9781405167208

SP - 291

EP - 311

BT - Fluorine in Medicinal Chemistry and Chemical Biology

PB - John Wiley & Sons, Ltd

ER -

Armstrong D, Cartwright MW, Parks EL, Pattison G, Sandford G, Slater R et al. Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. In Fluorine in Medicinal Chemistry and Chemical Biology. John Wiley & Sons, Ltd. 2009. p. 291-311 https://doi.org/10.1002/9781444312096.ch11