Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

David Armstrong; Matthew W. Cartwright; Emma L. Parks; Graham Pattison; Graham Sandford; Rachel Slater; Ian Wilson; John A. Christopher; David D. Miller; Paul W. Smith; Antonio Vong

doi:10.1002/9781444312096.ch11

Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, Ian Wilson, John A. Christopher, David D. Miller, Paul W. Smith, Antonio Vong

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › peer-review

Original language	English
Title of host publication	Fluorine in Medicinal Chemistry and Chemical Biology
Publisher	John Wiley & Sons, Ltd
Pages	291-311
Number of pages	21
ISBN (Print)	9781405167208
DOIs	https://doi.org/10.1002/9781444312096.ch11
Publication status	Published - 21 Apr 2009

Keywords

Advances in technology and high-throughput screening (HTS)
Biologically active heteroaromatic systems
Lipinski parameters (RO5) for predicting "drug-likeness" of potential molecular targets
Perfluorinated heteroaromatic systems as scaffolds for drug discovery
Perfluorinated heterocycles as core scaffolds
Privileged structures, core scaffolds and RAS in drug discovery process
Synthesis of 2-pyridone systems from pentafluoropyridine
Tetrafluoropyrimidine as a core scaffold

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10.1002/9781444312096.ch11

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Armstrong, D., Cartwright, M. W., Parks, E. L., Pattison, G., Sandford, G., Slater, R., Wilson, I., Christopher, J. A., Miller, D. D., Smith, P. W., & Vong, A. (2009). Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. In Fluorine in Medicinal Chemistry and Chemical Biology (pp. 291-311). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781444312096.ch11

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author = "David Armstrong and Cartwright, {Matthew W.} and Parks, {Emma L.} and Graham Pattison and Graham Sandford and Rachel Slater and Ian Wilson and Christopher, {John A.} and Miller, {David D.} and Smith, {Paul W.} and Antonio Vong",

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T1 - Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

AU - Armstrong, David

AU - Cartwright, Matthew W.

AU - Parks, Emma L.

AU - Pattison, Graham

AU - Sandford, Graham

AU - Slater, Rachel

AU - Wilson, Ian

AU - Christopher, John A.

AU - Miller, David D.

AU - Smith, Paul W.

AU - Vong, Antonio

PY - 2009/4/21

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KW - Biologically active heteroaromatic systems

KW - Lipinski parameters (RO5) for predicting "drug-likeness" of potential molecular targets

KW - Perfluorinated heteroaromatic systems as scaffolds for drug discovery

KW - Perfluorinated heterocycles as core scaffolds

KW - Privileged structures, core scaffolds and RAS in drug discovery process

KW - Synthesis of 2-pyridone systems from pentafluoropyridine

KW - Tetrafluoropyrimidine as a core scaffold

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U2 - 10.1002/9781444312096.ch11

DO - 10.1002/9781444312096.ch11

M3 - Chapter

AN - SCOPUS:84889333160

SN - 9781405167208

SP - 291

EP - 311

BT - Fluorine in Medicinal Chemistry and Chemical Biology

PB - John Wiley & Sons, Ltd

ER -

Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

Keywords

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