Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery

David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, Ian Wilson, John A. Christopher, David D. Miller, Paul W. Smith, Antonio Vong

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Original languageEnglish
Title of host publicationFluorine in Medicinal Chemistry and Chemical Biology
PublisherJohn Wiley & Sons, Ltd
Pages291-311
Number of pages21
ISBN (Print)9781405167208
DOIs
Publication statusPublished - 21 Apr 2009

Keywords

  • Advances in technology and high-throughput screening (HTS)
  • Biologically active heteroaromatic systems
  • Lipinski parameters (RO5) for predicting "drug-likeness" of potential molecular targets
  • Perfluorinated heteroaromatic systems as scaffolds for drug discovery
  • Perfluorinated heterocycles as core scaffolds
  • Privileged structures, core scaffolds and RAS in drug discovery process
  • Synthesis of 2-pyridone systems from pentafluoropyridine
  • Tetrafluoropyrimidine as a core scaffold

Cite this

Armstrong, D., Cartwright, M. W., Parks, E. L., Pattison, G., Sandford, G., Slater, R., Wilson, I., Christopher, J. A., Miller, D. D., Smith, P. W., & Vong, A. (2009). Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery. In Fluorine in Medicinal Chemistry and Chemical Biology (pp. 291-311). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781444312096.ch11