Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model

Iain Allan, Michael Wilson, H. Newman

Research output: Contribution to journalArticleResearchpeer-review

Abstract

45S5 Bioglass is a bioactive implant material which, in its particulate form, isused in the repair of periodontal defects. The surface reactions undergone by this materialin an aqueous environment may exert an antibacterial effect that would be beneficialto periodontal surgical treatment. Biofilms of Streptococcus sanguis, an early plaqueformer, and mixed species biofilms from a salivary inoculum grown under conditionssimilar to those associated with periodontal implants, were grown on particulate BioglassAin a constant depth film fermenter (CDFF). Control biofilms were grown on inert glassparticulates. At sample times of 3, 24 and 48 hours the viability of biofilms of S. sanguisgrown on BioglassA was significantly lower than for those grown on inert glass. In theexperiments with subgingivally-modelled mixed species biofilms, the total anaerobiccounts were significantly lower on BioglassA after 24 and 48 hours, but not 96 or 168hours, compared to inert glass. Thus, particulate BioglassA has the potential to reducebacterial colonisation of its surface in vivo, a feature relevant to post-surgicalperiodontal wound healing.
Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalClinical Oral Implants Research
Volume13
Publication statusPublished - 1 Jan 2002

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Microbial Viability
Biofilms
Glass
Streptococcus sanguis
Wound Healing
Bioglass
In Vitro Techniques

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title = "Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model",
abstract = "45S5 Bioglass is a bioactive implant material which, in its particulate form, isused in the repair of periodontal defects. The surface reactions undergone by this materialin an aqueous environment may exert an antibacterial effect that would be beneficialto periodontal surgical treatment. Biofilms of Streptococcus sanguis, an early plaqueformer, and mixed species biofilms from a salivary inoculum grown under conditionssimilar to those associated with periodontal implants, were grown on particulate BioglassAin a constant depth film fermenter (CDFF). Control biofilms were grown on inert glassparticulates. At sample times of 3, 24 and 48 hours the viability of biofilms of S. sanguisgrown on BioglassA was significantly lower than for those grown on inert glass. In theexperiments with subgingivally-modelled mixed species biofilms, the total anaerobiccounts were significantly lower on BioglassA after 24 and 48 hours, but not 96 or 168hours, compared to inert glass. Thus, particulate BioglassA has the potential to reducebacterial colonisation of its surface in vivo, a feature relevant to post-surgicalperiodontal wound healing.",
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Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model. / Allan, Iain; Wilson, Michael; Newman, H.

In: Clinical Oral Implants Research, Vol. 13, 01.01.2002, p. 53-58.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model

AU - Allan, Iain

AU - Wilson, Michael

AU - Newman, H.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - 45S5 Bioglass is a bioactive implant material which, in its particulate form, isused in the repair of periodontal defects. The surface reactions undergone by this materialin an aqueous environment may exert an antibacterial effect that would be beneficialto periodontal surgical treatment. Biofilms of Streptococcus sanguis, an early plaqueformer, and mixed species biofilms from a salivary inoculum grown under conditionssimilar to those associated with periodontal implants, were grown on particulate BioglassAin a constant depth film fermenter (CDFF). Control biofilms were grown on inert glassparticulates. At sample times of 3, 24 and 48 hours the viability of biofilms of S. sanguisgrown on BioglassA was significantly lower than for those grown on inert glass. In theexperiments with subgingivally-modelled mixed species biofilms, the total anaerobiccounts were significantly lower on BioglassA after 24 and 48 hours, but not 96 or 168hours, compared to inert glass. Thus, particulate BioglassA has the potential to reducebacterial colonisation of its surface in vivo, a feature relevant to post-surgicalperiodontal wound healing.

AB - 45S5 Bioglass is a bioactive implant material which, in its particulate form, isused in the repair of periodontal defects. The surface reactions undergone by this materialin an aqueous environment may exert an antibacterial effect that would be beneficialto periodontal surgical treatment. Biofilms of Streptococcus sanguis, an early plaqueformer, and mixed species biofilms from a salivary inoculum grown under conditionssimilar to those associated with periodontal implants, were grown on particulate BioglassAin a constant depth film fermenter (CDFF). Control biofilms were grown on inert glassparticulates. At sample times of 3, 24 and 48 hours the viability of biofilms of S. sanguisgrown on BioglassA was significantly lower than for those grown on inert glass. In theexperiments with subgingivally-modelled mixed species biofilms, the total anaerobiccounts were significantly lower on BioglassA after 24 and 48 hours, but not 96 or 168hours, compared to inert glass. Thus, particulate BioglassA has the potential to reducebacterial colonisation of its surface in vivo, a feature relevant to post-surgicalperiodontal wound healing.

M3 - Article

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EP - 58

JO - Clinical Oral Implants Research

JF - Clinical Oral Implants Research

SN - 0905-7161

ER -