Otoancorin knockout mice reveal inertia is the force for hearing

Thomas Weddell, P. Kevin Legan, Victoria A. Lukashkina, Richard J. Goodyear, Lindsy Welstead, Chistine Petit, Ian J. Russell, Andrei N. Lukashkin, Guy P. Richardson

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

We demonstrate that in Otoa-/- mice, in which the inner-ear-specific protein otoancorin is absent, excitation of the outer hair cells and cochlear amplification is normal. This finding is remarkable because the tectorial membrane (TM), although remaining functionally attached to the outer hair cell bundles, is completely detached from the spiral limbus. Therefore, as in ancestral vertebrate auditory organs, where inertia provides the excitatory force to the hair cells, it is the inertia of the TM that must be important for exciting the outer hair cells, setting the sensitivity of their transducer conductance, and determining the precise timing of cochlear amplification.

Original languageEnglish
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages139-140
Number of pages2
Volume1403
DOIs
Publication statusPublished - 12 Dec 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: 16 Jul 201122 Jul 2011

Workshop

Workshop11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period16/07/1122/07/11

Keywords

  • inner ear
  • otoancorin
  • outer hair cells
  • tectorial membrane

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  • Cite this

    Weddell, T., Legan, P. K., Lukashkina, V. A., Goodyear, R. J., Welstead, L., Petit, C., Russell, I. J., Lukashkin, A. N., & Richardson, G. P. (2011). Otoancorin knockout mice reveal inertia is the force for hearing. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (Vol. 1403, pp. 139-140) https://doi.org/10.1063/1.3658074