Otoancorin knockout mice reveal inertia is the force for hearing

Thomas Weddell; P. Kevin Legan; Victoria A. Lukashkina; Richard J. Goodyear; Lindsy Welstead; Chistine Petit; Ian J. Russell; Andrei N. Lukashkin; Guy P. Richardson

doi:10.1063/1.3658074

Otoancorin knockout mice reveal inertia is the force for hearing

Thomas Weddell, P. Kevin Legan, Victoria A. Lukashkina, Richard J. Goodyear, Lindsy Welstead, Chistine Petit, Ian J. Russell, Andrei N. Lukashkin, Guy P. Richardson

University of Brighton

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

Abstract

We demonstrate that in Otoa^-/- mice, in which the inner-ear-specific protein otoancorin is absent, excitation of the outer hair cells and cochlear amplification is normal. This finding is remarkable because the tectorial membrane (TM), although remaining functionally attached to the outer hair cell bundles, is completely detached from the spiral limbus. Therefore, as in ancestral vertebrate auditory organs, where inertia provides the excitatory force to the hair cells, it is the inertia of the TM that must be important for exciting the outer hair cells, setting the sensitivity of their transducer conductance, and determining the precise timing of cochlear amplification.

Original language	English
Title of host publication	What Fire is in Mine Ears
Subtitle of host publication	Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages	139-140
Number of pages	2
Volume	1403
DOIs	https://doi.org/10.1063/1.3658074
Publication status	Published - 12 Dec 2011
Event	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States Duration: 16 Jul 2011 → 22 Jul 2011

Workshop

Workshop	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
Country/Territory	United States
City	Williamstown, MA
Period	16/07/11 → 22/07/11

Keywords

inner ear
otoancorin
outer hair cells
tectorial membrane

Access to Document

10.1063/1.3658074

Cite this

Weddell, T., Legan, P. K., Lukashkina, V. A., Goodyear, R. J., Welstead, L., Petit, C., Russell, I. J., Lukashkin, A. N., & Richardson, G. P. (2011). Otoancorin knockout mice reveal inertia is the force for hearing. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (Vol. 1403, pp. 139-140) https://doi.org/10.1063/1.3658074

@inproceedings{e473d953204748b7b620a66a3257fd49,

title = "Otoancorin knockout mice reveal inertia is the force for hearing",

abstract = "We demonstrate that in Otoa-/- mice, in which the inner-ear-specific protein otoancorin is absent, excitation of the outer hair cells and cochlear amplification is normal. This finding is remarkable because the tectorial membrane (TM), although remaining functionally attached to the outer hair cell bundles, is completely detached from the spiral limbus. Therefore, as in ancestral vertebrate auditory organs, where inertia provides the excitatory force to the hair cells, it is the inertia of the TM that must be important for exciting the outer hair cells, setting the sensitivity of their transducer conductance, and determining the precise timing of cochlear amplification.",

keywords = "inner ear, otoancorin, outer hair cells, tectorial membrane",

author = "Thomas Weddell and Legan, {P. Kevin} and Lukashkina, {Victoria A.} and Goodyear, {Richard J.} and Lindsy Welstead and Chistine Petit and Russell, {Ian J.} and Lukashkin, {Andrei N.} and Richardson, {Guy P.}",

year = "2011",

month = dec,

day = "12",

doi = "10.1063/1.3658074",

language = "English",

isbn = "9780735409750",

volume = "1403",

pages = "139--140",

booktitle = "What Fire is in Mine Ears",

note = "11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics ; Conference date: 16-07-2011 Through 22-07-2011",

}

Weddell, T, Legan, PK, Lukashkina, VA, Goodyear, RJ, Welstead, L, Petit, C, Russell, IJ , Lukashkin, AN & Richardson, GP 2011, Otoancorin knockout mice reveal inertia is the force for hearing. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. vol. 1403, pp. 139-140, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 16/07/11. https://doi.org/10.1063/1.3658074

Otoancorin knockout mice reveal inertia is the force for hearing. / Weddell, Thomas; Legan, P. Kevin; Lukashkina, Victoria A. et al.
What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403 2011. p. 139-140.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Conference contribution with ISSN or ISBN › peer-review

TY - GEN

T1 - Otoancorin knockout mice reveal inertia is the force for hearing

AU - Weddell, Thomas

AU - Legan, P. Kevin

AU - Lukashkina, Victoria A.

AU - Goodyear, Richard J.

AU - Welstead, Lindsy

AU - Petit, Chistine

AU - Russell, Ian J.

AU - Lukashkin, Andrei N.

AU - Richardson, Guy P.

PY - 2011/12/12

Y1 - 2011/12/12

N2 - We demonstrate that in Otoa-/- mice, in which the inner-ear-specific protein otoancorin is absent, excitation of the outer hair cells and cochlear amplification is normal. This finding is remarkable because the tectorial membrane (TM), although remaining functionally attached to the outer hair cell bundles, is completely detached from the spiral limbus. Therefore, as in ancestral vertebrate auditory organs, where inertia provides the excitatory force to the hair cells, it is the inertia of the TM that must be important for exciting the outer hair cells, setting the sensitivity of their transducer conductance, and determining the precise timing of cochlear amplification.

AB - We demonstrate that in Otoa-/- mice, in which the inner-ear-specific protein otoancorin is absent, excitation of the outer hair cells and cochlear amplification is normal. This finding is remarkable because the tectorial membrane (TM), although remaining functionally attached to the outer hair cell bundles, is completely detached from the spiral limbus. Therefore, as in ancestral vertebrate auditory organs, where inertia provides the excitatory force to the hair cells, it is the inertia of the TM that must be important for exciting the outer hair cells, setting the sensitivity of their transducer conductance, and determining the precise timing of cochlear amplification.

KW - inner ear

KW - otoancorin

KW - outer hair cells

KW - tectorial membrane

UR - http://www.scopus.com/inward/record.url?scp=82955240853&partnerID=8YFLogxK

U2 - 10.1063/1.3658074

DO - 10.1063/1.3658074

M3 - Conference contribution with ISSN or ISBN

AN - SCOPUS:82955240853

SN - 9780735409750

VL - 1403

SP - 139

EP - 140

BT - What Fire is in Mine Ears

T2 - 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics

Y2 - 16 July 2011 through 22 July 2011

ER -

Otoancorin knockout mice reveal inertia is the force for hearing

Abstract

Workshop

Keywords

Access to Document

Other files and links

Fingerprint

Cite this