One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Daniel J. Leng; Conor M. Black; Graham Pattison

doi:10.1039/c5ob02468d

One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Daniel J. Leng
, Conor M. Black
, Graham Pattison

Applied Chemical Sciences Research Excellence Group

Research output: Contribution to journal › Article › peer-review

Abstract

Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

Original language	English
Pages (from-to)	1531-1535
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	5
DOIs	https://doi.org/10.1039/c5ob02468d
Publication status	Published - 16 Dec 2015

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10.1039/c5ob02468d

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title = "One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process",

abstract = "Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.",

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AU - Leng, Daniel J.

AU - Black, Conor M.

AU - Pattison, Graham

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Y1 - 2015/12/16

N2 - Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

AB - Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

UR - https://www.scopus.com/pages/publications/84956988380

U2 - 10.1039/c5ob02468d

DO - 10.1039/c5ob02468d

M3 - Article

AN - SCOPUS:84956988380

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EP - 1535

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 5

ER -

One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Abstract

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