One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Daniel J. Leng; Conor M. Black; Graham Pattison

doi:10.1039/c5ob02468d

One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Daniel J. Leng, Conor M. Black, Graham Pattison

Applied Chemical Sciences Research Excellence Group

Research output: Contribution to journal › Article › peer-review

Abstract

Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

Original language	English
Pages (from-to)	1531-1535
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	5
DOIs	https://doi.org/10.1039/c5ob02468d
Publication status	Published - 16 Dec 2015

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abstract = "Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.",

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AB - Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

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One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Abstract

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