One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Daniel J. Leng, Conor M. Black, Graham Pattison

Research output: Contribution to journalArticle

Abstract

Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

Original languageEnglish
Pages (from-to)1531-1535
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number5
DOIs
Publication statusPublished - 7 Feb 2016

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