Oligo (Poly(Ethylene Glycol)Fumarate)-Based Multicomponent Cryogels for Neural Tissue Replacement

Mohamed Zoughaib; Kenana Dayob; Svetlana Avdokushina; Marat I. Kamalov; Diana V. Salakhieva; Irina N. Savina; Igor A. Lavrov; Timur I. Abdullin

doi:10.3390/gels9020105

Oligo (Poly(Ethylene Glycol)Fumarate)-Based Multicomponent Cryogels for Neural Tissue Replacement

Mohamed Zoughaib, Kenana Dayob, Svetlana Avdokushina, Marat I. Kamalov, Diana V. Salakhieva, Irina N. Savina, Igor A. Lavrov, Timur I. Abdullin

Research output: Contribution to journal › Article › peer-review

Abstract

Synthetic hydrogels provide a promising platform to produce neural tissue analogs with improved control over structural, physical, and chemical properties. In this study, oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels were developed as a potential next-generation alternative to a non-porous OPF hydrogel previously proposed as an advanced biodegradable scaffold for spinal cord repair. A series of OPF cryogel conduits in combination with PEG diacrylate and 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) cationic monomers were synthesized and characterized. The contribution of each component to viscoelastic and hydration behaviors and porous structure was identified, and concentration relationships for these properties were revealed. The rheological properties of the materials corresponded to those of neural tissues and scaffolds, according to the reviewed data. A comparative assessment of adhesion, migration, and proliferation of neuronal cells in multicomponent cryogels was carried out to optimize cell-supporting characteristics. The results show that OPF-based cryogels can be used as a tunable synthetic scaffold for neural tissue repair with advantages over their hydrogel counterparts.

Original language	English
Article number	105
Number of pages	21
Journal	Gels
Volume	9
Issue number	2
DOIs	https://doi.org/10.3390/gels9020105
Publication status	Published - 25 Jan 2023

Bibliographical note

Funding Information:
This study was funded by the Russian Science Foundation according to the research project № 22-74-00082, https://rscf.ru/en/project/22-74-00082/, accessed on 4 January 2023 (synthesis and characterization of materials). The authors acknowledge the support of the subsidy allocated to Kazan Federal University (KFU) for the state assignment in the sphere of scientific activities (project FZSM-2022-0020) (design of multicomponent conduits).

Funding Information:
The authors thank Andrey V. Nemtarev (Alexander Butlerov Institute of Chemistry, KFU) for the NMR spectroscopy analysis, Amina G. Daminova (Interdisciplinary Center for Analytical Microscopy, KFU) for the microscopy analysis, and Ilnaz T. Rakipov and Aydar A. Akhmadyarov (Alexander Butlerov Institute of Chemistry, KFU) for the rheological analysis. This work is part of the Kazan Federal University strategic academic leadership program. Authors would like to acknowledge School of Applied Science Research invest fund, University of Brighton, for support.

Publisher Copyright:
© 2023 by the authors.

Keywords

Polymers and Plastics
Organic Chemistry
Biomaterials
Bioengineering
cationic monomer
polyethylene glycol
Article
cell-supporting properties
porous structure
oligo (poly (ethylene glycol) fumarate)
physicochemical properties
multicomponent cryogels
neuronal cells

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title = "Oligo (Poly(Ethylene Glycol)Fumarate)-Based Multicomponent Cryogels for Neural Tissue Replacement",

abstract = "Synthetic hydrogels provide a promising platform to produce neural tissue analogs with improved control over structural, physical, and chemical properties. In this study, oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels were developed as a potential next-generation alternative to a non-porous OPF hydrogel previously proposed as an advanced biodegradable scaffold for spinal cord repair. A series of OPF cryogel conduits in combination with PEG diacrylate and 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) cationic monomers were synthesized and characterized. The contribution of each component to viscoelastic and hydration behaviors and porous structure was identified, and concentration relationships for these properties were revealed. The rheological properties of the materials corresponded to those of neural tissues and scaffolds, according to the reviewed data. A comparative assessment of adhesion, migration, and proliferation of neuronal cells in multicomponent cryogels was carried out to optimize cell-supporting characteristics. The results show that OPF-based cryogels can be used as a tunable synthetic scaffold for neural tissue repair with advantages over their hydrogel counterparts.",

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author = "Mohamed Zoughaib and Kenana Dayob and Svetlana Avdokushina and Kamalov, {Marat I.} and Salakhieva, {Diana V.} and Savina, {Irina N.} and Lavrov, {Igor A.} and Abdullin, {Timur I.}",

note = "Funding Information: This study was funded by the Russian Science Foundation according to the research project № 22-74-00082, https://rscf.ru/en/project/22-74-00082/, accessed on 4 January 2023 (synthesis and characterization of materials). The authors acknowledge the support of the subsidy allocated to Kazan Federal University (KFU) for the state assignment in the sphere of scientific activities (project FZSM-2022-0020) (design of multicomponent conduits). Funding Information: The authors thank Andrey V. Nemtarev (Alexander Butlerov Institute of Chemistry, KFU) for the NMR spectroscopy analysis, Amina G. Daminova (Interdisciplinary Center for Analytical Microscopy, KFU) for the microscopy analysis, and Ilnaz T. Rakipov and Aydar A. Akhmadyarov (Alexander Butlerov Institute of Chemistry, KFU) for the rheological analysis. This work is part of the Kazan Federal University strategic academic leadership program. Authors would like to acknowledge School of Applied Science Research invest fund, University of Brighton, for support. Publisher Copyright: {\textcopyright} 2023 by the authors.",

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AU - Dayob, Kenana

AU - Avdokushina, Svetlana

AU - Kamalov, Marat I.

AU - Salakhieva, Diana V.

AU - Savina, Irina N.

AU - Lavrov, Igor A.

AU - Abdullin, Timur I.

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N2 - Synthetic hydrogels provide a promising platform to produce neural tissue analogs with improved control over structural, physical, and chemical properties. In this study, oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels were developed as a potential next-generation alternative to a non-porous OPF hydrogel previously proposed as an advanced biodegradable scaffold for spinal cord repair. A series of OPF cryogel conduits in combination with PEG diacrylate and 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) cationic monomers were synthesized and characterized. The contribution of each component to viscoelastic and hydration behaviors and porous structure was identified, and concentration relationships for these properties were revealed. The rheological properties of the materials corresponded to those of neural tissues and scaffolds, according to the reviewed data. A comparative assessment of adhesion, migration, and proliferation of neuronal cells in multicomponent cryogels was carried out to optimize cell-supporting characteristics. The results show that OPF-based cryogels can be used as a tunable synthetic scaffold for neural tissue repair with advantages over their hydrogel counterparts.

AB - Synthetic hydrogels provide a promising platform to produce neural tissue analogs with improved control over structural, physical, and chemical properties. In this study, oligo(poly(ethylene glycol) fumarate) (OPF)-based macroporous cryogels were developed as a potential next-generation alternative to a non-porous OPF hydrogel previously proposed as an advanced biodegradable scaffold for spinal cord repair. A series of OPF cryogel conduits in combination with PEG diacrylate and 2-(methacryloyloxy) ethyl-trimethylammonium chloride (MAETAC) cationic monomers were synthesized and characterized. The contribution of each component to viscoelastic and hydration behaviors and porous structure was identified, and concentration relationships for these properties were revealed. The rheological properties of the materials corresponded to those of neural tissues and scaffolds, according to the reviewed data. A comparative assessment of adhesion, migration, and proliferation of neuronal cells in multicomponent cryogels was carried out to optimize cell-supporting characteristics. The results show that OPF-based cryogels can be used as a tunable synthetic scaffold for neural tissue repair with advantages over their hydrogel counterparts.

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DO - 10.3390/gels9020105

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ER -

Oligo (Poly(Ethylene Glycol)Fumarate)-Based Multicomponent Cryogels for Neural Tissue Replacement

Abstract

Bibliographical note

Keywords

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