Novel roles for prestin in frequency tuning and neural excitation in the mouse cochlea

Marcia M. Mellado Lagarde, Markus Drexl, Andrei N. Lukashkin, Jian Zuo, Ian J. Russell

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNConference contribution with ISSN or ISBN

Abstract

The motor protein prestin in the outer hair cells is a prime candidate for the molecular amplifier that ensures the sensitivity, frequency tuning and dynamic range of the mammalian cochlea. Absence of prestin results in a 40-60 dB reduction in cochlear neural sensitivity. Here we show that sound-evoked basilar membrane (BM) vibrations in the basal cochleae of prestin-/- mice are as sensitive as those of their prestin+/+ siblings. BM vibrations in prestin-/- mice are, however, broadly tuned to a frequency ~ a half octave below the characteristic frequency (CF) of similar BM locations in prestin+/+ mice. The peak sensitivity of prestin+/+ BM tuning curves matches the neural thresholds, while prestin-/- BM tuning curves at the best frequency are > 50 dB more sensitive than the neural responses. We conclude that prestin influences properties of the cochlear partition that are crucial for BM frequency tuning and for converting its vibrations into neural excitation.

Original languageEnglish
Title of host publicationConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
EditorsDavid T. Kemp, Nigel P. Cooper
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages148-154
Number of pages7
ISBN (Electronic)9789812833778
Publication statusPublished - 1 Jan 2008
Event10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008 - Newcastle, United Kingdom
Duration: 27 Jul 200831 Jul 2008

Publication series

NameConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008

Conference

Conference10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008
CountryUnited Kingdom
CityNewcastle
Period27/07/0831/07/08

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  • Cite this

    Mellado Lagarde, M. M., Drexl, M., Lukashkin, A. N., Zuo, J., & Russell, I. J. (2008). Novel roles for prestin in frequency tuning and neural excitation in the mouse cochlea. In D. T. Kemp, & N. P. Cooper (Eds.), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008 (pp. 148-154). (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008). World Scientific Publishing Co. Pte Ltd.