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Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity
Florencia Ferraro
, Ileana Corvo
, Lucia Bergalli
, Andrea Ilarraz
, Mauricio Cabrera
, Jorge Gil
, Brian M. Susuki
, Conor R. Caffrey
, David J. Timson
, Xavier Robert
, Christophe Guillon
, Teresa Freire
, Guzmán Álvarez
Centre for Lifelong Health
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Keyphrases
Fasciola Hepatica
100%
Triosephosphate Isomerase
100%
Trematode
100%
Inactivator
100%
IC50
60%
F. Hepatica
40%
Triclabendazole
40%
Trematode Infection
40%
Mechanism of Action
20%
Interaction Mechanism
20%
Developmental Stages
20%
Chemotherapy
20%
Human Health
20%
Low Toxicity
20%
Drug Target
20%
Schistosoma Mansoni
20%
Animal Health
20%
Schistosomiasis
20%
Glycolytic Pathway
20%
Drug Candidates
20%
Microscale Thermophoresis
20%
Infected Mice
20%
Fascioliasis
20%
1,2,4-Thiadiazoles
20%
In Vitro Inhibition
20%
Juvenile Form
20%
Acute Toxicity
20%
Promising Drug
20%
Sulfonyl
20%
Toxicity in Vitro
20%
Agricultural Loss
20%
Pharmacology, Toxicology and Pharmaceutical Science
Trematode
100%
Fasciola Hepatica
100%
Triosephosphate Isomerase
100%
IC50
60%
Triclabendazole
40%
Trematodiasis
40%
Chemotherapy
20%
Schistosoma Mansoni
20%
Schistosomiasis
20%
Fascioliasis
20%
Acute Toxicity
20%
In Vitro Toxicity
20%
Sulfonyl
20%
Thiadiazoles
20%