Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide

Marat I. Kamalova, Igor A. Lavrova, Abdulla A. Yergeshova, Zulfira Y. Siraeva, Maxim E. Baltin, Albert A. Rizvanov, Svetlana V. Kuznetcova, Natalia V. Petrova, Irina Savina, Timur I. Abdullin

Research output: Contribution to journalArticle

Abstract

In this study the effect of oxidative modification on micellar and drug deliveryproperties of copolymers of ethylene oxide (EO) and propylene oxide (PO) wasinvestigated. Carboxylated trifunctional copolymers were synthesized in the reaction withchromium oxide (VI). We found that carboxylation significantly improved the uniformityand stability of polymeric micelles by inhibiting the microphase transition. Thecytotoxicity of copolymers was studied in relation to their aggregative state on two celltypes (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 inneuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidizedblock copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. Thecopolymer was also tested as an enhancer for topical drug delivery to the spinal cordwhen applied subdurally. The oxidized copolymer facilitated the penetration ofrhodamine 123 across spinal cord tissues and increased its intraspinal accumulation.These results show the potential of using oxidized EO/PO based polymers for noninvasivedelivery of protective drugs after spinal cord injury.
Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume140
DOIs
Publication statusPublished - 24 Dec 2015

Bibliographical note

© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • Amphiphilic polymers
  • Trifunctional copolymers of ethylene oxide and propylene oxide
  • Oxidative modification
  • Micelles
  • Drug delivery
  • Neural cells
  • Spinal cord
  • Traumatic injury

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  • Cite this

    Kamalova, M. I., Lavrova, I. A., Yergeshova, A. A., Siraeva, Z. Y., Baltin, M. E., Rizvanov, A. A., Kuznetcova, S. V., Petrova, N. V., Savina, I., & Abdullin, T. I. (2015). Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide. Colloids and Surfaces B: Biointerfaces, 140, 196-203. https://doi.org/10.1016/j.colsurfb.2015.12.035