No evidence of a common DNA variant profile specific to world class endurance athletes

Tuomo Rankinen, Noriyuki Fuku, Bernd Wolfarth, Guan Wang, Mark A. Sarzynski, Dmitry G. Alexeev, Ildus I. Ahmetov, Marcel R. Boulay, Pawel Cieszczyk, Nir Eynon, Maxim L. Filipenko, Fleur C. Garton, Edward V. Generozov, Vadim M. Govorun, Peter J. Houweling, T. Kawahara, Elena S. Kostryukova, Nickolay A. Kulemin, Andrey K. Larin, Agnieszka Maciejewska-KarłowskaM. Miyachi, M. Muniesa, H. Murakami, Elena A. Ospanova, Sandosh Padmanabhan, Alexander W. Pavlenko, Olga N. Pyankova, Catalina Santiago, Marek Sawczuk, Robert A. Scott, Vladimir V. Uyba, Thomas Yvert, Louis Perusse, Sujoy Ghosh, Rainer Rauramaa, Kathryn N. North, Alejandro Lucia, Yannis Pitsiladis, Claude Bouchard

Research output: Contribution to journalArticle

Abstract

There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 atGALNTL6locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2= 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.
Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalPLoS ONE
Volume11
Issue number1
DOIs
Publication statusPublished - 29 Jan 2016

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Athletes
DNA
Alleles
Exercise
Ethiopia
Kenya
Genome-Wide Association Study
Russia
Poland
Spain
Meta-Analysis
Case-Control Studies
Japan

Bibliographical note

© 2016 Rankinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this

Rankinen, T., Fuku, N., Wolfarth, B., Wang, G., Sarzynski, M. A., Alexeev, D. G., ... Bouchard, C. (2016). No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE, 11(1), 1-24. https://doi.org/10.1371/journal.pone.0147330
Rankinen, Tuomo ; Fuku, Noriyuki ; Wolfarth, Bernd ; Wang, Guan ; Sarzynski, Mark A. ; Alexeev, Dmitry G. ; Ahmetov, Ildus I. ; Boulay, Marcel R. ; Cieszczyk, Pawel ; Eynon, Nir ; Filipenko, Maxim L. ; Garton, Fleur C. ; Generozov, Edward V. ; Govorun, Vadim M. ; Houweling, Peter J. ; Kawahara, T. ; Kostryukova, Elena S. ; Kulemin, Nickolay A. ; Larin, Andrey K. ; Maciejewska-Karłowska, Agnieszka ; Miyachi, M. ; Muniesa, M. ; Murakami, H. ; Ospanova, Elena A. ; Padmanabhan, Sandosh ; Pavlenko, Alexander W. ; Pyankova, Olga N. ; Santiago, Catalina ; Sawczuk, Marek ; Scott, Robert A. ; Uyba, Vladimir V. ; Yvert, Thomas ; Perusse, Louis ; Ghosh, Sujoy ; Rauramaa, Rainer ; North, Kathryn N. ; Lucia, Alejandro ; Pitsiladis, Yannis ; Bouchard, Claude. / No evidence of a common DNA variant profile specific to world class endurance athletes. In: PLoS ONE. 2016 ; Vol. 11, No. 1. pp. 1-24.
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abstract = "There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 atGALNTL6locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2= 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.",
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Rankinen, T, Fuku, N, Wolfarth, B, Wang, G, Sarzynski, MA, Alexeev, DG, Ahmetov, II, Boulay, MR, Cieszczyk, P, Eynon, N, Filipenko, ML, Garton, FC, Generozov, EV, Govorun, VM, Houweling, PJ, Kawahara, T, Kostryukova, ES, Kulemin, NA, Larin, AK, Maciejewska-Karłowska, A, Miyachi, M, Muniesa, M, Murakami, H, Ospanova, EA, Padmanabhan, S, Pavlenko, AW, Pyankova, ON, Santiago, C, Sawczuk, M, Scott, RA, Uyba, VV, Yvert, T, Perusse, L, Ghosh, S, Rauramaa, R, North, KN, Lucia, A, Pitsiladis, Y & Bouchard, C 2016, 'No evidence of a common DNA variant profile specific to world class endurance athletes', PLoS ONE, vol. 11, no. 1, pp. 1-24. https://doi.org/10.1371/journal.pone.0147330

No evidence of a common DNA variant profile specific to world class endurance athletes. / Rankinen, Tuomo; Fuku, Noriyuki; Wolfarth, Bernd; Wang, Guan; Sarzynski, Mark A.; Alexeev, Dmitry G.; Ahmetov, Ildus I.; Boulay, Marcel R.; Cieszczyk, Pawel; Eynon, Nir; Filipenko, Maxim L.; Garton, Fleur C.; Generozov, Edward V.; Govorun, Vadim M.; Houweling, Peter J.; Kawahara, T.; Kostryukova, Elena S.; Kulemin, Nickolay A.; Larin, Andrey K.; Maciejewska-Karłowska, Agnieszka; Miyachi, M.; Muniesa, M.; Murakami, H.; Ospanova, Elena A.; Padmanabhan, Sandosh; Pavlenko, Alexander W.; Pyankova, Olga N.; Santiago, Catalina; Sawczuk, Marek; Scott, Robert A.; Uyba, Vladimir V.; Yvert, Thomas; Perusse, Louis; Ghosh, Sujoy; Rauramaa, Rainer; North, Kathryn N.; Lucia, Alejandro; Pitsiladis, Yannis; Bouchard, Claude.

In: PLoS ONE, Vol. 11, No. 1, 29.01.2016, p. 1-24.

Research output: Contribution to journalArticle

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T1 - No evidence of a common DNA variant profile specific to world class endurance athletes

AU - Rankinen, Tuomo

AU - Fuku, Noriyuki

AU - Wolfarth, Bernd

AU - Wang, Guan

AU - Sarzynski, Mark A.

AU - Alexeev, Dmitry G.

AU - Ahmetov, Ildus I.

AU - Boulay, Marcel R.

AU - Cieszczyk, Pawel

AU - Eynon, Nir

AU - Filipenko, Maxim L.

AU - Garton, Fleur C.

AU - Generozov, Edward V.

AU - Govorun, Vadim M.

AU - Houweling, Peter J.

AU - Kawahara, T.

AU - Kostryukova, Elena S.

AU - Kulemin, Nickolay A.

AU - Larin, Andrey K.

AU - Maciejewska-Karłowska, Agnieszka

AU - Miyachi, M.

AU - Muniesa, M.

AU - Murakami, H.

AU - Ospanova, Elena A.

AU - Padmanabhan, Sandosh

AU - Pavlenko, Alexander W.

AU - Pyankova, Olga N.

AU - Santiago, Catalina

AU - Sawczuk, Marek

AU - Scott, Robert A.

AU - Uyba, Vladimir V.

AU - Yvert, Thomas

AU - Perusse, Louis

AU - Ghosh, Sujoy

AU - Rauramaa, Rainer

AU - North, Kathryn N.

AU - Lucia, Alejandro

AU - Pitsiladis, Yannis

AU - Bouchard, Claude

N1 - © 2016 Rankinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2016/1/29

Y1 - 2016/1/29

N2 - There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 atGALNTL6locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2= 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.

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