Abstract
Introduction
Sleep disturbances are commonly reported in people living with Alzheimer's disease (AD), but it is currently unknown whether night-to-night variation in sleep predicts day-to-day variation in vigilance, cognition, mood, and behavior (daytime measures).
Methods
Subjective and objective sleep and daytime measures were collected daily for 2 weeks in 15 participants with mild AD, eight participants with mild cognitive impairment (MCI), and 22 participants with no cognitive impairment (NCI). Associations between daytime measures and four principal components of sleep (duration, quality, continuity, and latency) were quantified using mixed-model regression.
Results
Sleepiness, alertness, contentedness, everyday memory errors, serial subtraction, and behavioral problems were predicted by at least one of the components of sleep, and in particular sleep duration and continuity. Associations between variations in sleep and daytime measures were linear or quadratic and often different between participants with AD and those with NCI.
Discussion
These findings imply that daytime functioning in people with AD may be improved by interventions that target sleep continuity.
Sleep disturbances are commonly reported in people living with Alzheimer's disease (AD), but it is currently unknown whether night-to-night variation in sleep predicts day-to-day variation in vigilance, cognition, mood, and behavior (daytime measures).
Methods
Subjective and objective sleep and daytime measures were collected daily for 2 weeks in 15 participants with mild AD, eight participants with mild cognitive impairment (MCI), and 22 participants with no cognitive impairment (NCI). Associations between daytime measures and four principal components of sleep (duration, quality, continuity, and latency) were quantified using mixed-model regression.
Results
Sleepiness, alertness, contentedness, everyday memory errors, serial subtraction, and behavioral problems were predicted by at least one of the components of sleep, and in particular sleep duration and continuity. Associations between variations in sleep and daytime measures were linear or quadratic and often different between participants with AD and those with NCI.
Discussion
These findings imply that daytime functioning in people with AD may be improved by interventions that target sleep continuity.
| Original language | English |
|---|---|
| Article number | e12303 |
| Number of pages | 11 |
| Journal | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 16 May 2022 |
Bibliographical note
Funding Information:The authors are grateful to all the participants and their families who dedicated their time to this study. They thank Dr Nayantara Santhi for providing training and expertise for the acquisition of actigraphy data, Dr Jeewaka Mendis for advice on SAS programming, Dr Richard Hoile for help with data collection, and Miss Abbie Harris for help with data entry. The conduct of the study was supported by the Centre for Dementia Studies, Brighton & Sussex Medical School (BSMS), and Sussex Partnership NHS Foundation Trust. SB was funded by the Centre for Dementia Studies, BSMS, to carry out the research in a Dementia Research Fellowship role. The analysis was supported by the UK Dementia Research Institute Care and Research Technology Centre at Imperial College London and the University of Surrey, Guildford, UK.
Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Keywords
- Alzheimer's disease
- actigraphy
- behavior
- cognition
- dementia
- memory
- mild cognitive impairment
- mood
- older adults
- sleep
- vigilance