Nanoparticle-mediated gene delivery to tumour neovasculature

A.R. Reynolds, S.M. Moghimi, K. Hodivala-Dilke

Research output: Contribution to journalArticle

Abstract

The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.
Original languageEnglish
Pages (from-to)2-4
Number of pages3
JournalTrends in molecular medicine
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2003

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Nanoparticles
Genes
Neoplasms
Integrins
Pharmacology
Therapeutics

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Reynolds, A.R. ; Moghimi, S.M. ; Hodivala-Dilke, K. / Nanoparticle-mediated gene delivery to tumour neovasculature. In: Trends in molecular medicine. 2003 ; Vol. 9, No. 1. pp. 2-4.
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Nanoparticle-mediated gene delivery to tumour neovasculature. / Reynolds, A.R.; Moghimi, S.M.; Hodivala-Dilke, K.

In: Trends in molecular medicine, Vol. 9, No. 1, 01.2003, p. 2-4.

Research output: Contribution to journalArticle

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