N-Functionalised polyfluoropyridazin-3(2H)-one derivatives

Graham Pattison, Graham Sandford, Dmitry S. Yufit, Judith A.K. Howard, John A. Christopher, David D. Miller

    Research output: Contribution to journalArticlepeer-review


    Pyridazin-3(2H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones as the core scaffolds is described.

    Original languageEnglish
    Pages (from-to)8844-8850
    Number of pages7
    Issue number43
    Publication statusPublished - 24 Oct 2009


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