N-Functionalised polyfluoropyridazin-3(2H)-one derivatives

Graham Pattison; Graham Sandford; Dmitry S. Yufit; Judith A.K. Howard; John A. Christopher; David D. Miller

doi:10.1016/j.tet.2009.08.050

N-Functionalised polyfluoropyridazin-3(2H)-one derivatives

Graham Pattison, Graham Sandford, Dmitry S. Yufit, Judith A.K. Howard, John A. Christopher, David D. Miller

Research output: Contribution to journal › Article › peer-review

Abstract

Pyridazin-3(2H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones as the core scaffolds is described.

Original language	English
Pages (from-to)	8844-8850
Number of pages	7
Journal	Tetrahedron
Volume	65
Issue number	43
DOIs	https://doi.org/10.1016/j.tet.2009.08.050
Publication status	Published - 24 Oct 2009

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abstract = "Pyridazin-3(2H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones as the core scaffolds is described.",

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AU - Pattison, Graham

AU - Sandford, Graham

AU - Yufit, Dmitry S.

AU - Howard, Judith A.K.

AU - Christopher, John A.

AU - Miller, David D.

PY - 2009/10/24

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N2 - Pyridazin-3(2H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones as the core scaffolds is described.

AB - Pyridazin-3(2H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones as the core scaffolds is described.

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JO - Tetrahedron

JF - Tetrahedron

IS - 43

ER -

N-Functionalised polyfluoropyridazin-3(2H)-one derivatives

Abstract

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