N-Functionalised polyfluoropyridazin-3(2H)-one derivatives

Graham Pattison, Graham Sandford, Dmitry S. Yufit, Judith A.K. Howard, John A. Christopher, David D. Miller

Research output: Contribution to journalArticle

Abstract

Pyridazin-3(2H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but, in general, synthesis of polysubstituted analogues can be very difficult to achieve. An approach to the syntheses of polyfunctional pyridazinone systems involving sequential nucleophilic substitution reactions of N-aryl and N-THP protected 4,5,6-trifluoropyridazin-3(2H)-ones as the core scaffolds is described.

Original languageEnglish
Pages (from-to)8844-8850
Number of pages7
JournalTetrahedron
Volume65
Issue number43
DOIs
Publication statusPublished - 24 Oct 2009

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Agrochemicals
Drug Industry
Derivatives
Scaffolds
Substitution reactions
Pharmaceutical Preparations
Industry
4,5,6-trifluoropyridazin-3(2H)-one

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Pattison, G., Sandford, G., Yufit, D. S., Howard, J. A. K., Christopher, J. A., & Miller, D. D. (2009). N-Functionalised polyfluoropyridazin-3(2H)-one derivatives. Tetrahedron, 65(43), 8844-8850. https://doi.org/10.1016/j.tet.2009.08.050
Pattison, Graham ; Sandford, Graham ; Yufit, Dmitry S. ; Howard, Judith A.K. ; Christopher, John A. ; Miller, David D. / N-Functionalised polyfluoropyridazin-3(2H)-one derivatives. In: Tetrahedron. 2009 ; Vol. 65, No. 43. pp. 8844-8850.
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Pattison, G, Sandford, G, Yufit, DS, Howard, JAK, Christopher, JA & Miller, DD 2009, 'N-Functionalised polyfluoropyridazin-3(2H)-one derivatives', Tetrahedron, vol. 65, no. 43, pp. 8844-8850. https://doi.org/10.1016/j.tet.2009.08.050

N-Functionalised polyfluoropyridazin-3(2H)-one derivatives. / Pattison, Graham; Sandford, Graham; Yufit, Dmitry S.; Howard, Judith A.K.; Christopher, John A.; Miller, David D.

In: Tetrahedron, Vol. 65, No. 43, 24.10.2009, p. 8844-8850.

Research output: Contribution to journalArticle

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AU - Sandford, Graham

AU - Yufit, Dmitry S.

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Pattison G, Sandford G, Yufit DS, Howard JAK, Christopher JA, Miller DD. N-Functionalised polyfluoropyridazin-3(2H)-one derivatives. Tetrahedron. 2009 Oct 24;65(43):8844-8850. https://doi.org/10.1016/j.tet.2009.08.050