Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy

Edward J. Lynch, Angela Sheerin, Christopher J.L. Silwood, Martin C. Grootveld

Research output: Contribution to journalArticle

Abstract

High resolution 1 H nuclear magnetic resonance (NMR) spectroscopy was employed to conduct a multicomponent investigation of the oxidation of salivary biomolecules by peroxoborate present in a tooth-whitening dentifrice formulation. The results acquired demonstrated that peroxoborate gave rise to the oxidative decarboxylation of the hydrogen peroxide scavenger pyruvate, a reaction generating acetate and C02 as products. Experiments performed on chemical model systems confirmed the oxidative consumption of pyruvate by dentifrice-derived peroxoborate, and also revealed that the salivary electron donors cysteine and methionine ( precursors to volatile sulphur compounds), wereoxidised to cystine and methionine sulphoxide respectively. The biochemical and periodontal significance of these results is discussed.
Original languageEnglish
Pages (from-to)65-84
Number of pages20
JournalJournal of Inorganic Biochemistry
Volume73
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 1999

Keywords

  • Peroxoborate
  • Tooth-whitening agent
  • Human saliva
  • NMR spectroscopy
  • Pyruvate

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