Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy

Edward J. Lynch; Angela Sheerin; Christopher J.L. Silwood; Martin C. Grootveld

doi:10.1016/S0162-0134(98)10092-2

Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy

Edward J. Lynch, Angela Sheerin, Christopher J.L. Silwood, Martin C. Grootveld

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

High resolution 1 H nuclear magnetic resonance (NMR) spectroscopy was employed to conduct a multicomponent investigation of the oxidation of salivary biomolecules by peroxoborate present in a tooth-whitening dentifrice formulation. The results acquired demonstrated that peroxoborate gave rise to the oxidative decarboxylation of the hydrogen peroxide scavenger pyruvate, a reaction generating acetate and C02 as products. Experiments performed on chemical model systems confirmed the oxidative consumption of pyruvate by dentifrice-derived peroxoborate, and also revealed that the salivary electron donors cysteine and methionine ( precursors to volatile sulphur compounds), wereoxidised to cystine and methionine sulphoxide respectively. The biochemical and periodontal significance of these results is discussed.

Original language	English
Pages (from-to)	65-84
Number of pages	20
Journal	Journal of Inorganic Biochemistry
Volume	73
Issue number	1-2
DOIs	https://doi.org/10.1016/S0162-0134(98)10092-2
Publication status	Published - 1 Jan 1999

Keywords

Peroxoborate
Tooth-whitening agent
Human saliva
NMR spectroscopy
Pyruvate

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title = "Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy",

abstract = "High resolution 1 H nuclear magnetic resonance (NMR) spectroscopy was employed to conduct a multicomponent investigation of the oxidation of salivary biomolecules by peroxoborate present in a tooth-whitening dentifrice formulation. The results acquired demonstrated that peroxoborate gave rise to the oxidative decarboxylation of the hydrogen peroxide scavenger pyruvate, a reaction generating acetate and C02 as products. Experiments performed on chemical model systems confirmed the oxidative consumption of pyruvate by dentifrice-derived peroxoborate, and also revealed that the salivary electron donors cysteine and methionine ( precursors to volatile sulphur compounds), wereoxidised to cystine and methionine sulphoxide respectively. The biochemical and periodontal significance of these results is discussed.",

keywords = "Peroxoborate, Tooth-whitening agent, Human saliva, NMR spectroscopy, Pyruvate",

author = "Lynch, {Edward J.} and Angela Sheerin and Silwood, {Christopher J.L.} and Grootveld, {Martin C.}",

year = "1999",

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doi = "10.1016/S0162-0134(98)10092-2",

language = "English",

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journal = "Journal of Inorganic Biochemistry",

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Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy. / Lynch, Edward J.; Sheerin, Angela; Silwood, Christopher J.L. et al.
In: Journal of Inorganic Biochemistry, Vol. 73, No. 1-2, 01.01.1999, p. 65-84.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy

AU - Lynch, Edward J.

AU - Sheerin, Angela

AU - Silwood, Christopher J.L.

AU - Grootveld, Martin C.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - High resolution 1 H nuclear magnetic resonance (NMR) spectroscopy was employed to conduct a multicomponent investigation of the oxidation of salivary biomolecules by peroxoborate present in a tooth-whitening dentifrice formulation. The results acquired demonstrated that peroxoborate gave rise to the oxidative decarboxylation of the hydrogen peroxide scavenger pyruvate, a reaction generating acetate and C02 as products. Experiments performed on chemical model systems confirmed the oxidative consumption of pyruvate by dentifrice-derived peroxoborate, and also revealed that the salivary electron donors cysteine and methionine ( precursors to volatile sulphur compounds), wereoxidised to cystine and methionine sulphoxide respectively. The biochemical and periodontal significance of these results is discussed.

AB - High resolution 1 H nuclear magnetic resonance (NMR) spectroscopy was employed to conduct a multicomponent investigation of the oxidation of salivary biomolecules by peroxoborate present in a tooth-whitening dentifrice formulation. The results acquired demonstrated that peroxoborate gave rise to the oxidative decarboxylation of the hydrogen peroxide scavenger pyruvate, a reaction generating acetate and C02 as products. Experiments performed on chemical model systems confirmed the oxidative consumption of pyruvate by dentifrice-derived peroxoborate, and also revealed that the salivary electron donors cysteine and methionine ( precursors to volatile sulphur compounds), wereoxidised to cystine and methionine sulphoxide respectively. The biochemical and periodontal significance of these results is discussed.

KW - Peroxoborate

KW - Tooth-whitening agent

KW - Human saliva

KW - NMR spectroscopy

KW - Pyruvate

U2 - 10.1016/S0162-0134(98)10092-2

DO - 10.1016/S0162-0134(98)10092-2

M3 - Article

SN - 0162-0134

VL - 73

SP - 65

EP - 84

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 1-2

ER -

Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy

Abstract

Keywords

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