Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics

S. Kockisch, G.D. Rees, J. Tsibouklis, John Smart

Research output: Contribution to journalArticle

Abstract

The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated ‘in use’ conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.
Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

chitosan
mouth
polymers
sodium dodecyl sulfate
emulsions
evaporation
teeth
buffers
kinetics
methodology

Keywords

  • Polymer microspheres
  • Triclosan
  • Double emulsion
  • Bioadhesion
  • Oral cavity
  • Release kinetics

Cite this

@article{abf563db175c444ba2de1bcbcb375bb1,
title = "Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics",
abstract = "The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated ‘in use’ conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.",
keywords = "Polymer microspheres, Triclosan, Double emulsion, Bioadhesion, Oral cavity, Release kinetics",
author = "S. Kockisch and G.D. Rees and J. Tsibouklis and John Smart",
year = "2005",
month = "1",
doi = "10.1016/j.ejpb.2004.07.007",
language = "English",
volume = "59",
pages = "207--216",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
number = "1",

}

Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics. / Kockisch, S.; Rees, G.D.; Tsibouklis, J.; Smart, John.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 59, No. 1, 01.2005, p. 207-216.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics

AU - Kockisch, S.

AU - Rees, G.D.

AU - Tsibouklis, J.

AU - Smart, John

PY - 2005/1

Y1 - 2005/1

N2 - The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated ‘in use’ conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.

AB - The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated ‘in use’ conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.

KW - Polymer microspheres

KW - Triclosan

KW - Double emulsion

KW - Bioadhesion

KW - Oral cavity

KW - Release kinetics

U2 - 10.1016/j.ejpb.2004.07.007

DO - 10.1016/j.ejpb.2004.07.007

M3 - Article

VL - 59

SP - 207

EP - 216

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 1

ER -