Mitochondrial haplogroups associated with elite Kenyan athlete status

Robert A. Scott, Noriyuki Fuku, V.O. Onywera, M. Boit, R.H. Wilson, M. Tanaka, W.H. Goodwin, Yannis Pitsiladis

Research output: Contribution to journalArticle

Abstract

The maternal inheritance of mitochondrial DNA (mtDNA) has enabled construction of detailed phylogenies. Analysis of key polymorphisms from these phylogenies allows mtDNA to be assigned to haplogroups, which have been associated with elite endurance performance. PURPOSE To compare the frequencies of mtDNA haplogroups found in elite Kenyan athletes with those in the general Kenyan population. METHODS DNA samples were obtained from 221 national level Kenyan athletes (N), 70 international Kenyan athletes (I), and 85 members of the general Kenyan population (C). mtDNA haplogroups were classified by sequencing 340 bases of hypervariable section (HVS I) and by genotyping known restriction sites. Frequency differences between groups were assessed using exact tests of population differentiation. RESULTS The haplogroup distribution of national (P = 0.023) and international athletes (P < 0.001) differed significantly from controls, with international athletes showing a greater proportion of L0 haplogroups (C = 15%, N = 18%, I = 30%) and lower proportion of L3* haplogroups (C = 48%, N = 36%, I = 26%). Although a high number of international athletes originated from the Rift Valley province relative to controls (C = 20%, N = 65%, I = 81%), subjects from this province did not differ in haplogroup distribution from other regions (P = 0.23). Nor did Bantu subjects differ from Nilotic (P = 0.12) despite an overrepresentation of Nilotic languages among the athletes. CONCLUSIONS International athletes differed in their mtDNA haplogroup distribution relative to the general Kenyan population. They displayed an excess of L0 haplogroups and a dearth of L3* haplogroups. These findings suggest that mtDNA haplogroups are influential in elite Kenyan distance running, although population stratification cannot be ruled out.
Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalMedicine and science in sports and exercise
Volume41
Issue number1
DOIs
Publication statusPublished - 31 Jan 2009

Keywords

  • Genetics
  • mtDNA
  • Africa
  • Runners
  • Athletic Performance

Fingerprint Dive into the research topics of 'Mitochondrial haplogroups associated with elite Kenyan athlete status'. Together they form a unique fingerprint.

Cite this