Microelectrode investigation of neuroneal ageing from a single identified neurone

Bhavik Patel; M. Arundell; K.H. Parker; Mark Yeoman; D. O'Hare

doi:10.1039/C0CP00310G

Microelectrode investigation of neuroneal ageing from a single identified neurone

Bhavik Patel
, M. Arundell
, K.H. Parker
, Mark Yeoman
, D. O'Hare

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

Original language	English
Pages (from-to)	10065-10072
Number of pages	8
Journal	Physical Chemistry Chemical Physics
Volume	12
Issue number	34
DOIs	https://doi.org/10.1039/C0CP00310G
Publication status	Published - 12 Jul 2010

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AU - O'Hare, D.

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AB - Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

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DO - 10.1039/C0CP00310G

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JF - Physical Chemistry Chemical Physics

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Microelectrode investigation of neuroneal ageing from a single identified neurone

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