Methods for the Synthesis of α,α-Difluoroketones

Graham Pattison

Research output: Contribution to journalLiterature reviewpeer-review


α,α-Difluoroketones are valuable compounds and can be used as synthetic intermediates for the synthesis of fluorinated molecules, but they also have a direct application in medicinal chemistry, particularly as inhibitors for hydrolytic enzymes. This Microreview will summarize the major methods currently available for the synthesis of α,α-difluoroketones, highlighting methods involving direct C–F bond formation, as well as those using pre-difluorinated building blocks.

Original languageEnglish
Pages (from-to)3520-3540
Number of pages21
JournalEuropean Journal of Organic Chemistry
Issue number27
Publication statusPublished - 1 Aug 2018


  • Enzyme inhibitors
  • Fluorinated compounds
  • Fluorinated radicals
  • Fluorination
  • Fluoroenolates
  • Fluoroketones


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