Methods for the Synthesis of α,α-Difluoroketones

Research output: Contribution to journalLiterature review

Abstract

α,α-Difluoroketones are valuable compounds and can be used as synthetic intermediates for the synthesis of fluorinated molecules, but they also have a direct application in medicinal chemistry, particularly as inhibitors for hydrolytic enzymes. This Microreview will summarize the major methods currently available for the synthesis of α,α-difluoroketones, highlighting methods involving direct C–F bond formation, as well as those using pre-difluorinated building blocks.

Original languageEnglish
Pages (from-to)3520-3540
Number of pages21
JournalEuropean Journal of Organic Chemistry
Volume2018
Issue number27
DOIs
Publication statusPublished - 1 Aug 2018

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Enzyme Inhibitors
synthesis
inhibitors
enzymes
chemistry
Molecules
molecules
Pharmaceutical Chemistry

Keywords

  • Enzyme inhibitors
  • Fluorinated compounds
  • Fluorinated radicals
  • Fluorination
  • Fluoroenolates
  • Fluoroketones

Cite this

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title = "Methods for the Synthesis of α,α-Difluoroketones",
abstract = "α,α-Difluoroketones are valuable compounds and can be used as synthetic intermediates for the synthesis of fluorinated molecules, but they also have a direct application in medicinal chemistry, particularly as inhibitors for hydrolytic enzymes. This Microreview will summarize the major methods currently available for the synthesis of α,α-difluoroketones, highlighting methods involving direct C–F bond formation, as well as those using pre-difluorinated building blocks.",
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Methods for the Synthesis of α,α-Difluoroketones. / Pattison, Graham.

In: European Journal of Organic Chemistry, Vol. 2018, No. 27, 01.08.2018, p. 3520-3540.

Research output: Contribution to journalLiterature review

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KW - Enzyme inhibitors

KW - Fluorinated compounds

KW - Fluorinated radicals

KW - Fluorination

KW - Fluoroenolates

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