Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Minyahil Tadesse Boltena; Ziad El-Khatib; Abraham Sahilemichael Kebede; Benedict Oppong Asamoah; Appiah Seth Christopher Yaw; Kassim Kamara; Phénix Constant Assogba; Andualem Tadesse Boltena; Hawult Taye Adane; Elifaged Hailemeskel; Mulatu Biru

doi:10.3390/ijerph19095444

Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Minyahil Tadesse Boltena, Ziad El-Khatib, Abraham Sahilemichael Kebede, Benedict Oppong Asamoah, Appiah Seth Christopher Yaw, Kassim Kamara, Phénix Constant Assogba, Andualem Tadesse Boltena, Hawult Taye Adane, Elifaged Hailemeskel, Mulatu Biru

School of Sport and Health Sciences

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Abstract

Malaria and helminthic co-infection during pregnancy causes fetomaternal haemorrhage and foetal growth retardation. This study determined the pooled burden of pregnancy malaria and helminthic co-infection in sub-Saharan Africa. CINAHL, EMBASE, Google Scholar, Scopus, PubMed, and Web of Science databases were used to retrieve data from the literature, without restricting language and publication year. The Joanna Briggs Institute's critical appraisal tool for prevalence studies was used for quality assessment. STATA Version 14.0 was used to conduct the meta-analysis. The I² statistics and Egger's test were used to test heterogeneity and publication bias. The random-effects model was used to estimate the pooled prevalence at a 95% confidence interval (CI). The review protocol has been registered in PROSPERO, with the number CRD42019144812. In total, 24 studies (n = 14,087 participants) were identified in this study. The pooled analysis revealed that 20% of pregnant women were co-infected by malaria and helminths in sub-Saharan Africa. The pooled prevalence of malaria and helminths were 33% and 35%, respectively. The most prevalent helminths were Hookworm (48%), Ascaris lumbricoides (37%), and Trichuris trichiura (15%). Significantly higher malaria and helminthic co-infection during pregnancy were observed. Health systems in sub-Saharan Africa must implement home-grown innovative solutions to underpin context-specific policies for the early initiation of effective intermittent preventive therapy.

Original language	English
Article number	5444
Number of pages	22
Journal	International journal of environmental research and public health
Volume	19
Issue number	9
DOIs	https://doi.org/10.3390/ijerph19095444
Publication status	Published - 29 Apr 2022

Bibliographical note

Funding Information:
The Armauer Hansen Research Institute for enabling us and granting access to the databases and The Joanna Briggs Institute (JBI), for helping us with access to the databases and development of the review protocol. The Evidence-Based Healthcare Centre at Jimma University in Ethiopia provided us with a comprehensive systematic review training opportunity.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Sub-Saharan Africa
Co-infection
Comorbidity
Helminthic Infections
Pregnancy Malaria
Humans
Helminthiasis
Malaria
Prevalence
Pregnancy
Pregnant Women
Africa South of the Sahara
Female
Coinfection

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Cite this

Tadesse Boltena, M., El-Khatib, Z., Kebede, A. S., Asamoah, B. O., Yaw, A. S. C., Kamara, K., Constant Assogba, P., Tadesse Boltena, A., Adane, H. T., Hailemeskel, E., & Biru, M. (2022). Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. International journal of environmental research and public health, 19(9), Article 5444. https://doi.org/10.3390/ijerph19095444

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abstract = "Malaria and helminthic co-infection during pregnancy causes fetomaternal haemorrhage and foetal growth retardation. This study determined the pooled burden of pregnancy malaria and helminthic co-infection in sub-Saharan Africa. CINAHL, EMBASE, Google Scholar, Scopus, PubMed, and Web of Science databases were used to retrieve data from the literature, without restricting language and publication year. The Joanna Briggs Institute's critical appraisal tool for prevalence studies was used for quality assessment. STATA Version 14.0 was used to conduct the meta-analysis. The I2 statistics and Egger's test were used to test heterogeneity and publication bias. The random-effects model was used to estimate the pooled prevalence at a 95% confidence interval (CI). The review protocol has been registered in PROSPERO, with the number CRD42019144812. In total, 24 studies (n = 14,087 participants) were identified in this study. The pooled analysis revealed that 20% of pregnant women were co-infected by malaria and helminths in sub-Saharan Africa. The pooled prevalence of malaria and helminths were 33% and 35%, respectively. The most prevalent helminths were Hookworm (48%), Ascaris lumbricoides (37%), and Trichuris trichiura (15%). Significantly higher malaria and helminthic co-infection during pregnancy were observed. Health systems in sub-Saharan Africa must implement home-grown innovative solutions to underpin context-specific policies for the early initiation of effective intermittent preventive therapy.",

keywords = "Sub-Saharan Africa, Co-infection, Comorbidity, Helminthic Infections, Pregnancy Malaria, Humans, Helminthiasis, Malaria, Prevalence, Pregnancy, Pregnant Women, Africa South of the Sahara, Female, Coinfection",

author = "{Tadesse Boltena}, Minyahil and Ziad El-Khatib and Kebede, {Abraham Sahilemichael} and Asamoah, {Benedict Oppong} and Yaw, {Appiah Seth Christopher} and Kassim Kamara and {Constant Assogba}, Ph{\'e}nix and {Tadesse Boltena}, Andualem and Adane, {Hawult Taye} and Elifaged Hailemeskel and Mulatu Biru",

note = "Funding Information: The Armauer Hansen Research Institute for enabling us and granting access to the databases and The Joanna Briggs Institute (JBI), for helping us with access to the databases and development of the review protocol. The Evidence-Based Healthcare Centre at Jimma University in Ethiopia provided us with a comprehensive systematic review training opportunity. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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Tadesse Boltena, M, El-Khatib, Z, Kebede, AS, Asamoah, BO, Yaw, ASC, Kamara, K, Constant Assogba, P, Tadesse Boltena, A, Adane, HT, Hailemeskel, E & Biru, M 2022, 'Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis', International journal of environmental research and public health, vol. 19, no. 9, 5444. https://doi.org/10.3390/ijerph19095444

Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. / Tadesse Boltena, Minyahil; El-Khatib, Ziad; Kebede, Abraham Sahilemichael et al.
In: International journal of environmental research and public health, Vol. 19, No. 9, 5444, 29.04.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa

T2 - A Systematic Review and Meta-Analysis

AU - Tadesse Boltena, Minyahil

AU - El-Khatib, Ziad

AU - Kebede, Abraham Sahilemichael

AU - Asamoah, Benedict Oppong

AU - Yaw, Appiah Seth Christopher

AU - Kamara, Kassim

AU - Constant Assogba, Phénix

AU - Tadesse Boltena, Andualem

AU - Adane, Hawult Taye

AU - Hailemeskel, Elifaged

AU - Biru, Mulatu

N1 - Funding Information: The Armauer Hansen Research Institute for enabling us and granting access to the databases and The Joanna Briggs Institute (JBI), for helping us with access to the databases and development of the review protocol. The Evidence-Based Healthcare Centre at Jimma University in Ethiopia provided us with a comprehensive systematic review training opportunity. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/4/29

Y1 - 2022/4/29

N2 - Malaria and helminthic co-infection during pregnancy causes fetomaternal haemorrhage and foetal growth retardation. This study determined the pooled burden of pregnancy malaria and helminthic co-infection in sub-Saharan Africa. CINAHL, EMBASE, Google Scholar, Scopus, PubMed, and Web of Science databases were used to retrieve data from the literature, without restricting language and publication year. The Joanna Briggs Institute's critical appraisal tool for prevalence studies was used for quality assessment. STATA Version 14.0 was used to conduct the meta-analysis. The I2 statistics and Egger's test were used to test heterogeneity and publication bias. The random-effects model was used to estimate the pooled prevalence at a 95% confidence interval (CI). The review protocol has been registered in PROSPERO, with the number CRD42019144812. In total, 24 studies (n = 14,087 participants) were identified in this study. The pooled analysis revealed that 20% of pregnant women were co-infected by malaria and helminths in sub-Saharan Africa. The pooled prevalence of malaria and helminths were 33% and 35%, respectively. The most prevalent helminths were Hookworm (48%), Ascaris lumbricoides (37%), and Trichuris trichiura (15%). Significantly higher malaria and helminthic co-infection during pregnancy were observed. Health systems in sub-Saharan Africa must implement home-grown innovative solutions to underpin context-specific policies for the early initiation of effective intermittent preventive therapy.

AB - Malaria and helminthic co-infection during pregnancy causes fetomaternal haemorrhage and foetal growth retardation. This study determined the pooled burden of pregnancy malaria and helminthic co-infection in sub-Saharan Africa. CINAHL, EMBASE, Google Scholar, Scopus, PubMed, and Web of Science databases were used to retrieve data from the literature, without restricting language and publication year. The Joanna Briggs Institute's critical appraisal tool for prevalence studies was used for quality assessment. STATA Version 14.0 was used to conduct the meta-analysis. The I2 statistics and Egger's test were used to test heterogeneity and publication bias. The random-effects model was used to estimate the pooled prevalence at a 95% confidence interval (CI). The review protocol has been registered in PROSPERO, with the number CRD42019144812. In total, 24 studies (n = 14,087 participants) were identified in this study. The pooled analysis revealed that 20% of pregnant women were co-infected by malaria and helminths in sub-Saharan Africa. The pooled prevalence of malaria and helminths were 33% and 35%, respectively. The most prevalent helminths were Hookworm (48%), Ascaris lumbricoides (37%), and Trichuris trichiura (15%). Significantly higher malaria and helminthic co-infection during pregnancy were observed. Health systems in sub-Saharan Africa must implement home-grown innovative solutions to underpin context-specific policies for the early initiation of effective intermittent preventive therapy.

KW - Sub-Saharan Africa

KW - Co-infection

KW - Comorbidity

KW - Helminthic Infections

KW - Pregnancy Malaria

KW - Humans

KW - Helminthiasis

KW - Malaria

KW - Prevalence

KW - Pregnancy

KW - Pregnant Women

KW - Africa South of the Sahara

KW - Female

KW - Coinfection

U2 - 10.3390/ijerph19095444

DO - 10.3390/ijerph19095444

M3 - Article

SN - 1661-7827

VL - 19

JO - International journal of environmental research and public health

JF - International journal of environmental research and public health

IS - 9

M1 - 5444

ER -

Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Abstract

Bibliographical note

Keywords

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