TY - JOUR
T1 - Magnetic Field Triggerable Macroporous PDMS Sponge Loaded with an Anticancer Drug, 5-Fluorouracil
AU - Shi, Kejing
AU - Aviles-Espinosa, Rodrigo
AU - Rendon-Morales, Elizabeth
AU - Woodbine, Lisa
AU - Salvage, Jonathan P.
AU - Maniruzzaman, Mohammed
AU - Nokhodchi, Ali
N1 - Publisher Copyright:
©
PY - 2021/1/11
Y1 - 2021/1/11
N2 - This study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl iron (CI) and magnetite Fe3O4 nanopowders were embedded as magnetosensitive materials in PDMS resins for the fabrication of macroporous sponges via a sugar-template process. The process is environmentally friendly and simple. The fabricated interconnected macroporous magnetic particles loaded PDMS sponges possess flexible skeletons and good recyclability because of their recoverability after compression (deformation) without any breakdown. The prepared magnetic PDMS sponges were evaluated for their morphology (SEM and EDS), porosity (absorbency), elastic modulus, deformation under a magnetic field, thermostability, and in vitro cell studies. All physicochemical and magnetomechanical analysis confirmed that the optimized magnetic-field-sensitive PDMS sponge can provide an efficient method for delivering an on-demand dose of anticancer drug solutions at a specific location and timing with the aid of controlled magnetic fields.
AB - This study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl iron (CI) and magnetite Fe3O4 nanopowders were embedded as magnetosensitive materials in PDMS resins for the fabrication of macroporous sponges via a sugar-template process. The process is environmentally friendly and simple. The fabricated interconnected macroporous magnetic particles loaded PDMS sponges possess flexible skeletons and good recyclability because of their recoverability after compression (deformation) without any breakdown. The prepared magnetic PDMS sponges were evaluated for their morphology (SEM and EDS), porosity (absorbency), elastic modulus, deformation under a magnetic field, thermostability, and in vitro cell studies. All physicochemical and magnetomechanical analysis confirmed that the optimized magnetic-field-sensitive PDMS sponge can provide an efficient method for delivering an on-demand dose of anticancer drug solutions at a specific location and timing with the aid of controlled magnetic fields.
KW - 5-fluorouracil
KW - carbonyl iron
KW - iron oxide
KW - Magnetic field
KW - nanoparticles
KW - personalized medicine
KW - polydimethylsiloxane
KW - sponge
KW - triggerable drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=85099065448&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.0c01608
DO - 10.1021/acsbiomaterials.0c01608
M3 - Article
C2 - 33455208
AN - SCOPUS:85099065448
SN - 2373-9878
VL - 7
SP - 180
EP - 195
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 1
ER -