Magnetic Field Triggerable Macroporous PDMS Sponge Loaded with an Anticancer Drug, 5-Fluorouracil

Kejing Shi, Rodrigo Aviles-Espinosa, Elizabeth Rendon-Morales, Lisa Woodbine, Jonathan P. Salvage, Mohammed Maniruzzaman, Ali Nokhodchi

Research output: Contribution to journalArticlepeer-review


This study aims to prepare, optimize, and characterize magnetic-field-sensitive sugar-templated polydimethylsiloxane (PDMS) sponges for localized delivery of an anticancer drug, 5-fluorouracil (FLU). For this purpose, different concentrations of carbonyl iron (CI) and magnetite Fe3O4 nanopowders were embedded as magnetosensitive materials in PDMS resins for the fabrication of macroporous sponges via a sugar-template process. The process is environmentally friendly and simple. The fabricated interconnected macroporous magnetic particles loaded PDMS sponges possess flexible skeletons and good recyclability because of their recoverability after compression (deformation) without any breakdown. The prepared magnetic PDMS sponges were evaluated for their morphology (SEM and EDS), porosity (absorbency), elastic modulus, deformation under a magnetic field, thermostability, and in vitro cell studies. All physicochemical and magnetomechanical analysis confirmed that the optimized magnetic-field-sensitive PDMS sponge can provide an efficient method for delivering an on-demand dose of anticancer drug solutions at a specific location and timing with the aid of controlled magnetic fields.

Original languageEnglish
Pages (from-to)180-195
Number of pages16
JournalACS Biomaterials Science and Engineering
Issue number1
Publication statusPublished - 11 Jan 2021

Bibliographical note

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  • 5-fluorouracil
  • carbonyl iron
  • iron oxide
  • Magnetic field
  • nanoparticles
  • personalized medicine
  • polydimethylsiloxane
  • sponge
  • triggerable drug delivery system


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