Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu; Qiang Fu; Dominika Wilczok; Kejun Ying; Aaron King; Adam Antebi; Aleksandar Vojta; Alexandra Stolzing; Alexey Moskalev; Anastasia Georgievskaya; Andrea B Maier; Andrea Olsen; Anja Groth; Anna Katharina Simon; Anne Brunet; Aisyah Jamil; Anton Kulaga; Asif Bhatti; Benjamin Yaden; Bente Klarlund Pedersen; Björn Schumacher; Boris Djordjevic; Brian Kennedy; Chieh Chen; Christine Yuan Huang; Christoph U Correll; Coleen T Murphy; Collin Y Ewald; Danica Chen; Dario Riccardo Valenzano; Dariusz Sołdacki; David Erritzoe; David Meyer; David A Sinclair; Eduardo Nunes Chini; Emma C Teeling; Eric Morgen; Eric Verdin; Erik Vernet; Estefano Pinilla; Evandro F Fang; Evelyne Bischof; Evi M Mercken; Fabian Finger; Folkert Kuipers; Frank W Pun; Gabor Gyülveszi; Gabriele Civiletto; Garri Zmudze; Gil Blander; Harold A Pincus; Joshua McClure; James L Kirkland; James Peyer; Jamie N Justice; Jan Vijg; Jennifer R Gruhn; Jerry McLaughlin; Joan Mannick; João Passos; Joseph A Baur; Joe Betts-LaCroix; John M Sedivy; John R Speakman; Jordan Shlain; Julia von Maltzahn; Katrin I Andreasson; Kelsey Moody; Konstantinos Palikaras; Kristen Fortney; Laura J Niedernhofer; Lene Juel Rasmussen; Liesbeth M Veenhoff; Lisa Melton; Luigi Ferrucci; Marco Quarta; Maria Koval; Maria Marinova; Mark Hamalainen; Maximilian Unfried; Michael S Ringel; Milos Filipovic; Mourad Topors; Natalia Mitin; Nawal Roy; Nika Pintar; Nir Barzilai; Paolo Binetti; Parminder Singh; Paul Kohlhaas; Paul D Robbins; Paul Rubin; Peter O Fedichev; Petrina Kamya; Pura Muñoz-Canoves; Rafael de Cabo; Richard G A Faragher; Rob Konrad; Roberto Ripa; Robin Mansukhani; Sabrina Büttner; Sara A Wickström; Sebastian Brunemeier; Sergey Jakimov; Shan Luo; Sharon Rosenzweig-Lipson; Shih-Yin Tsai; Stefanie Dimmeler; Thomas A Rando; Tim R Peterson; Tina Woods; Tony Wyss-Coray; Toren Finkel; Tzipora Strauss; Vadim N Gladyshev; Valter D Longo; Varun B Dwaraka; Vera Gorbunova; Victoria A Acosta-Rodríguez; Vincenzo Sorrentino; Vittorio Sebastiano; Wenbin Li; Yousin Suh; Alex Zhavoronkov; Morten Scheibye-Knudsen; Daniela Bakula

doi:10.18632/aging.206135

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu
, Qiang Fu
, Dominika Wilczok
, Kejun Ying
, Aaron King
, Adam Antebi
, Aleksandar Vojta
, Alexandra Stolzing
, Alexey Moskalev
, Anastasia Georgievskaya
, Andrea B Maier
, Andrea Olsen
, Anja Groth
, Anna Katharina Simon
, Anne Brunet
, Aisyah Jamil
, Anton Kulaga
, Asif Bhatti
, Benjamin Yaden
, Bente Klarlund Pedersen

Björn Schumacher, Boris Djordjevic, Brian Kennedy, Chieh Chen, Christine Yuan Huang, Christoph U Correll, Coleen T Murphy, Collin Y Ewald, Danica Chen, Dario Riccardo Valenzano, Dariusz Sołdacki, David Erritzoe, David Meyer, David A Sinclair, Eduardo Nunes Chini, Emma C Teeling, Eric Morgen, Eric Verdin, Erik Vernet, Estefano Pinilla, Evandro F Fang, Evelyne Bischof, Evi M Mercken, Fabian Finger, Folkert Kuipers, Frank W Pun, Gabor Gyülveszi, Gabriele Civiletto, Garri Zmudze, Gil Blander, Harold A Pincus, Joshua McClure, James L Kirkland, James Peyer, Jamie N Justice, Jan Vijg, Jennifer R Gruhn, Jerry McLaughlin, Joan Mannick, João Passos, Joseph A Baur, Joe Betts-LaCroix, John M Sedivy, John R Speakman, Jordan Shlain, Julia von Maltzahn, Katrin I Andreasson, Kelsey Moody, Konstantinos Palikaras, Kristen Fortney, Laura J Niedernhofer, Lene Juel Rasmussen, Liesbeth M Veenhoff, Lisa Melton, Luigi Ferrucci, Marco Quarta, Maria Koval, Maria Marinova, Mark Hamalainen, Maximilian Unfried, Michael S Ringel, Milos Filipovic, Mourad Topors, Natalia Mitin, Nawal Roy, Nika Pintar, Nir Barzilai, Paolo Binetti, Parminder Singh, Paul Kohlhaas, Paul D Robbins, Paul Rubin, Peter O Fedichev, Petrina Kamya, Pura Muñoz-Canoves, Rafael de Cabo, Richard G A Faragher, Rob Konrad, Roberto Ripa, Robin Mansukhani, Sabrina Büttner, Sara A Wickström, Sebastian Brunemeier, Sergey Jakimov, Shan Luo, Sharon Rosenzweig-Lipson, Shih-Yin Tsai, Stefanie Dimmeler, Thomas A Rando, Tim R Peterson, Tina Woods, Tony Wyss-Coray, Toren Finkel, Tzipora Strauss, Vadim N Gladyshev, Valter D Longo, Varun B Dwaraka, Vera Gorbunova, Victoria A Acosta-Rodríguez, Vincenzo Sorrentino, Vittorio Sebastiano, Wenbin Li, Yousin Suh, Alex Zhavoronkov, Morten Scheibye-Knudsen, Daniela Bakula

School of Applied Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Original language	English
Pages (from-to)	12955-12976
Number of pages	22
Journal	Aging
Volume	16
Issue number	20
DOIs	https://doi.org/10.18632/aging.206135
Publication status	Published - 16 Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

biotechnology
healthy longevity
artificial intelligence

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10.18632/aging.206135Licence: CC BY

aging-v16i20-206135Final published version, 1.22 MBLicence: CC BY

Cite this

Lyu, Y.-X., Fu, Q., Wilczok, D., Ying, K., King, A., Antebi, A., Vojta, A., Stolzing, A., Moskalev, A., Georgievskaya, A., Maier, A. B., Olsen, A., Groth, A., Simon, A. K., Brunet, A., Jamil, A., Kulaga, A., Bhatti, A., Yaden, B., ... Bakula, D. (2024). Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging, 16(20), 12955-12976. https://doi.org/10.18632/aging.206135

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title = "Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity",

abstract = "The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.",

keywords = "biotechnology, healthy longevity, artificial intelligence",

author = "Yu-Xuan Lyu and Qiang Fu and Dominika Wilczok and Kejun Ying and Aaron King and Adam Antebi and Aleksandar Vojta and Alexandra Stolzing and Alexey Moskalev and Anastasia Georgievskaya and Maier, \{Andrea B\} and Andrea Olsen and Anja Groth and Simon, \{Anna Katharina\} and Anne Brunet and Aisyah Jamil and Anton Kulaga and Asif Bhatti and Benjamin Yaden and Pedersen, \{Bente Klarlund\} and Bj{\"o}rn Schumacher and Boris Djordjevic and Brian Kennedy and Chieh Chen and Huang, \{Christine Yuan\} and Correll, \{Christoph U\} and Murphy, \{Coleen T\} and Ewald, \{Collin Y\} and Danica Chen and Valenzano, \{Dario Riccardo\} and Dariusz So{\l}dacki and David Erritzoe and David Meyer and Sinclair, \{David A\} and Chini, \{Eduardo Nunes\} and Teeling, \{Emma C\} and Eric Morgen and Eric Verdin and Erik Vernet and Estefano Pinilla and Fang, \{Evandro F\} and Evelyne Bischof and Mercken, \{Evi M\} and Fabian Finger and Folkert Kuipers and Pun, \{Frank W\} and Gabor Gy{\"u}lveszi and Gabriele Civiletto and Garri Zmudze and Gil Blander and Pincus, \{Harold A\} and Joshua McClure and Kirkland, \{James L\} and James Peyer and Justice, \{Jamie N\} and Jan Vijg and Gruhn, \{Jennifer R\} and Jerry McLaughlin and Joan Mannick and Jo{\~a}o Passos and Baur, \{Joseph A\} and Joe Betts-LaCroix and Sedivy, \{John M\} and Speakman, \{John R\} and Jordan Shlain and \{von Maltzahn\}, Julia and Andreasson, \{Katrin I\} and Kelsey Moody and Konstantinos Palikaras and Kristen Fortney and Niedernhofer, \{Laura J\} and Rasmussen, \{Lene Juel\} and Veenhoff, \{Liesbeth M\} and Lisa Melton and Luigi Ferrucci and Marco Quarta and Maria Koval and Maria Marinova and Mark Hamalainen and Maximilian Unfried and Ringel, \{Michael S\} and Milos Filipovic and Mourad Topors and Natalia Mitin and Nawal Roy and Nika Pintar and Nir Barzilai and Paolo Binetti and Parminder Singh and Paul Kohlhaas and Robbins, \{Paul D\} and Paul Rubin and Fedichev, \{Peter O\} and Petrina Kamya and Pura Mu{\~n}oz-Canoves and \{de Cabo\}, Rafael and Faragher, \{Richard G A\} and Rob Konrad and Roberto Ripa and Robin Mansukhani and Sabrina B{\"u}ttner and Wickstr{\"o}m, \{Sara A\} and Sebastian Brunemeier and Sergey Jakimov and Shan Luo and Sharon Rosenzweig-Lipson and Shih-Yin Tsai and Stefanie Dimmeler and Rando, \{Thomas A\} and Peterson, \{Tim R\} and Tina Woods and Tony Wyss-Coray and Toren Finkel and Tzipora Strauss and Gladyshev, \{Vadim N\} and Longo, \{Valter D\} and Dwaraka, \{Varun B\} and Vera Gorbunova and Acosta-Rodr{\'i}guez, \{Victoria A\} and Vincenzo Sorrentino and Vittorio Sebastiano and Wenbin Li and Yousin Suh and Alex Zhavoronkov and Morten Scheibye-Knudsen and Daniela Bakula",

note = "Publisher Copyright: {\textcopyright} 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2024",

month = oct,

day = "16",

doi = "10.18632/aging.206135",

language = "English",

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Lyu, Y-X, Fu, Q, Wilczok, D, Ying, K, King, A, Antebi, A, Vojta, A, Stolzing, A, Moskalev, A, Georgievskaya, A, Maier, AB, Olsen, A, Groth, A, Simon, AK, Brunet, A, Jamil, A, Kulaga, A, Bhatti, A, Yaden, B, Pedersen, BK, Schumacher, B, Djordjevic, B, Kennedy, B, Chen, C, Huang, CY, Correll, CU, Murphy, CT, Ewald, CY, Chen, D, Valenzano, DR, Sołdacki, D, Erritzoe, D, Meyer, D, Sinclair, DA, Chini, EN, Teeling, EC, Morgen, E, Verdin, E, Vernet, E, Pinilla, E, Fang, EF, Bischof, E, Mercken, EM, Finger, F, Kuipers, F, Pun, FW, Gyülveszi, G, Civiletto, G, Zmudze, G, Blander, G, Pincus, HA, McClure, J, Kirkland, JL, Peyer, J, Justice, JN, Vijg, J, Gruhn, JR, McLaughlin, J, Mannick, J, Passos, J, Baur, JA, Betts-LaCroix, J, Sedivy, JM, Speakman, JR, Shlain, J, von Maltzahn, J, Andreasson, KI, Moody, K, Palikaras, K, Fortney, K, Niedernhofer, LJ, Rasmussen, LJ, Veenhoff, LM, Melton, L, Ferrucci, L, Quarta, M, Koval, M, Marinova, M, Hamalainen, M, Unfried, M, Ringel, MS, Filipovic, M, Topors, M, Mitin, N, Roy, N, Pintar, N, Barzilai, N, Binetti, P, Singh, P, Kohlhaas, P, Robbins, PD, Rubin, P, Fedichev, PO, Kamya, P, Muñoz-Canoves, P, de Cabo, R, Faragher, RGA, Konrad, R, Ripa, R, Mansukhani, R, Büttner, S, Wickström, SA, Brunemeier, S, Jakimov, S, Luo, S, Rosenzweig-Lipson, S, Tsai, S-Y, Dimmeler, S, Rando, TA, Peterson, TR, Woods, T, Wyss-Coray, T, Finkel, T, Strauss, T, Gladyshev, VN, Longo, VD, Dwaraka, VB, Gorbunova, V, Acosta-Rodríguez, VA, Sorrentino, V, Sebastiano, V, Li, W, Suh, Y, Zhavoronkov, A, Scheibye-Knudsen, M & Bakula, D 2024, 'Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity', Aging, vol. 16, no. 20, pp. 12955-12976. https://doi.org/10.18632/aging.206135

TY - JOUR

T1 - Longevity biotechnology

T2 - bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

AU - Lyu, Yu-Xuan

AU - Fu, Qiang

AU - Wilczok, Dominika

AU - Ying, Kejun

AU - King, Aaron

AU - Antebi, Adam

AU - Vojta, Aleksandar

AU - Stolzing, Alexandra

AU - Moskalev, Alexey

AU - Georgievskaya, Anastasia

AU - Maier, Andrea B

AU - Olsen, Andrea

AU - Groth, Anja

AU - Simon, Anna Katharina

AU - Brunet, Anne

AU - Jamil, Aisyah

AU - Kulaga, Anton

AU - Bhatti, Asif

AU - Yaden, Benjamin

AU - Pedersen, Bente Klarlund

AU - Schumacher, Björn

AU - Djordjevic, Boris

AU - Kennedy, Brian

AU - Chen, Chieh

AU - Huang, Christine Yuan

AU - Correll, Christoph U

AU - Murphy, Coleen T

AU - Ewald, Collin Y

AU - Chen, Danica

AU - Valenzano, Dario Riccardo

AU - Sołdacki, Dariusz

AU - Erritzoe, David

AU - Meyer, David

AU - Sinclair, David A

AU - Chini, Eduardo Nunes

AU - Teeling, Emma C

AU - Morgen, Eric

AU - Verdin, Eric

AU - Vernet, Erik

AU - Pinilla, Estefano

AU - Fang, Evandro F

AU - Bischof, Evelyne

AU - Mercken, Evi M

AU - Finger, Fabian

AU - Kuipers, Folkert

AU - Pun, Frank W

AU - Gyülveszi, Gabor

AU - Civiletto, Gabriele

AU - Zmudze, Garri

AU - Blander, Gil

AU - Pincus, Harold A

AU - McClure, Joshua

AU - Kirkland, James L

AU - Peyer, James

AU - Justice, Jamie N

AU - Vijg, Jan

AU - Gruhn, Jennifer R

AU - McLaughlin, Jerry

AU - Mannick, Joan

AU - Passos, João

AU - Baur, Joseph A

AU - Betts-LaCroix, Joe

AU - Sedivy, John M

AU - Speakman, John R

AU - Shlain, Jordan

AU - von Maltzahn, Julia

AU - Andreasson, Katrin I

AU - Moody, Kelsey

AU - Palikaras, Konstantinos

AU - Fortney, Kristen

AU - Niedernhofer, Laura J

AU - Rasmussen, Lene Juel

AU - Veenhoff, Liesbeth M

AU - Melton, Lisa

AU - Ferrucci, Luigi

AU - Quarta, Marco

AU - Koval, Maria

AU - Marinova, Maria

AU - Hamalainen, Mark

AU - Unfried, Maximilian

AU - Ringel, Michael S

AU - Filipovic, Milos

AU - Topors, Mourad

AU - Mitin, Natalia

AU - Roy, Nawal

AU - Pintar, Nika

AU - Barzilai, Nir

AU - Binetti, Paolo

AU - Singh, Parminder

AU - Kohlhaas, Paul

AU - Robbins, Paul D

AU - Rubin, Paul

AU - Fedichev, Peter O

AU - Kamya, Petrina

AU - Muñoz-Canoves, Pura

AU - de Cabo, Rafael

AU - Faragher, Richard G A

AU - Konrad, Rob

AU - Ripa, Roberto

AU - Mansukhani, Robin

AU - Büttner, Sabrina

AU - Wickström, Sara A

AU - Brunemeier, Sebastian

AU - Jakimov, Sergey

AU - Luo, Shan

AU - Rosenzweig-Lipson, Sharon

AU - Tsai, Shih-Yin

AU - Dimmeler, Stefanie

AU - Rando, Thomas A

AU - Peterson, Tim R

AU - Woods, Tina

AU - Wyss-Coray, Tony

AU - Finkel, Toren

AU - Strauss, Tzipora

AU - Gladyshev, Vadim N

AU - Longo, Valter D

AU - Dwaraka, Varun B

AU - Gorbunova, Vera

AU - Acosta-Rodríguez, Victoria A

AU - Sorrentino, Vincenzo

AU - Sebastiano, Vittorio

AU - Li, Wenbin

AU - Suh, Yousin

AU - Zhavoronkov, Alex

AU - Scheibye-Knudsen, Morten

AU - Bakula, Daniela

N1 - Publisher Copyright: © 2024 Lyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2024/10/16

Y1 - 2024/10/16

N2 - The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

AB - The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

KW - biotechnology

KW - healthy longevity

KW - artificial intelligence

UR - https://www.scopus.com/pages/publications/85208049247

U2 - 10.18632/aging.206135

DO - 10.18632/aging.206135

M3 - Article

C2 - 39418098

SN - 1945-4589

VL - 16

SP - 12955

EP - 12976

JO - Aging

JF - Aging

IS - 20

ER -

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

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