Lectin-mediated drug delivery in the oral cavity

Research output: Contribution to journalArticle

Abstract

The delivery of therapeutic agents to, or via, the oral cavity is limited by the efficient removal mechanisms that exist in this area. Lectins are proteins or glycoproteins that bind to specific sugar residues, and can, therefore, interact with the glycoconjugates present on cell surfaces or salivary mucins. Endogenous lectins could also be used as points of attachment for carbohydrate-containing delivery systems. This review considers the possibility of using lectins as targeting agents within the oral cavity and reports on some of the limited number of studies completed to date. As lectins are multifunctional molecules, the possibility of using them as both targeting and therapeutic agents is considered. Lectin-containing delivery systems are a potential innovation for targeted and prolonged therapy within the oral cavity, but considerations such as toxicity and cost will need to be addressed before their routine use becomes a reality.
Original languageEnglish
Pages (from-to)481-489
Number of pages9
JournalAdvanced Drug Delivery Reviews
Volume56
Issue number4
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Lectins
Mouth
Pharmaceutical Preparations
Glycoconjugates
Mucins
Glycoproteins
Therapeutics
Carbohydrates
Costs and Cost Analysis
Proteins

Keywords

  • Oral cavity
  • Lectin
  • Drug delivery

Cite this

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Lectin-mediated drug delivery in the oral cavity. / Smart, John.

In: Advanced Drug Delivery Reviews, Vol. 56, No. 4, 03.2004, p. 481-489.

Research output: Contribution to journalArticle

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