TY - JOUR
T1 - Insulin-like growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years
AU - Rogers, Imogen
AU - Metcalfe, C.
AU - Gunnell, D.
AU - Emmett, P.
AU - Dunger, D.
AU - Holly, J.
PY - 2006/5
Y1 - 2006/5
N2 - IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7–8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9–10 yr.
AB - IGF-I, a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study, we investigated the association of IGF-I measured at 5 and 7–8 yr with growth in height and the components of height (leg and trunk length) from 5 yr to 9–10 yr.
M3 - Article
SN - 0021-972X
VL - 91
SP - 2514
EP - 2519
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 7
ER -