Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

Barbara Szendrei, Domingo González-Lamuño, Teresa Amigo, Guan Wang, Yannis Pitsiladis, Pedro J. Benito, Carmen Gomez-Candela, Francisco J. Calderón, Rocío Cupeiro

Research output: Contribution to journalArticle

Abstract

The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (ρ = 0.019, 2.5 kg) and BMI (ρ = 0.019, 0.88 kg) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (ρ = 0.036), in addition to an interaction with exercise for fat mass (ρ = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (ρ = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.
Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalApplied Physiology, Nutrition, and Metabolism
Volume41
Issue number3
DOIs
Publication statusPublished - 25 Nov 2015

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Body Composition
Weight Loss
Fats
Body Weight
Body Mass Index
Exercise
Weights and Measures
Glutamic Acid
Weight Reduction Programs
Lipolysis
Glutamine
Tryptophan
Adrenergic Receptors
Energy Metabolism
Arginine
Alleles
Diet
Genes

Keywords

  • β-adrenergic receptors
  • weight loss
  • body composition
  • Gln27Glu and Trp64Arg
  • exercise and diet

Cite this

Szendrei, Barbara ; González-Lamuño, Domingo ; Amigo, Teresa ; Wang, Guan ; Pitsiladis, Yannis ; Benito, Pedro J. ; Gomez-Candela, Carmen ; Calderón, Francisco J. ; Cupeiro, Rocío. / Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention. In: Applied Physiology, Nutrition, and Metabolism. 2015 ; Vol. 41, No. 3. pp. 307-314.
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Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention. / Szendrei, Barbara; González-Lamuño, Domingo; Amigo, Teresa; Wang, Guan; Pitsiladis, Yannis; Benito, Pedro J.; Gomez-Candela, Carmen; Calderón, Francisco J.; Cupeiro, Rocío.

In: Applied Physiology, Nutrition, and Metabolism, Vol. 41, No. 3, 25.11.2015, p. 307-314.

Research output: Contribution to journalArticle

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T1 - Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

AU - Szendrei, Barbara

AU - González-Lamuño, Domingo

AU - Amigo, Teresa

AU - Wang, Guan

AU - Pitsiladis, Yannis

AU - Benito, Pedro J.

AU - Gomez-Candela, Carmen

AU - Calderón, Francisco J.

AU - Cupeiro, Rocío

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N2 - The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (ρ = 0.019, 2.5 kg) and BMI (ρ = 0.019, 0.88 kg) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (ρ = 0.036), in addition to an interaction with exercise for fat mass (ρ = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (ρ = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.

AB - The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (ρ = 0.019, 2.5 kg) and BMI (ρ = 0.019, 0.88 kg) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (ρ = 0.036), in addition to an interaction with exercise for fat mass (ρ = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (ρ = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.

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KW - weight loss

KW - body composition

KW - Gln27Glu and Trp64Arg

KW - exercise and diet

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