Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life

C. Venter, B. Pereira, Jane D. Grundy, C.B. Clayton, G. Roberts, B. Higgins, Taraneh Dean

Research output: Contribution to journalArticle

Abstract

Background There are very few population-based studies investigating the incidence of food hypersensitivity during the first year of life. Objective To determine the incidence of parentally reported food hypersensitivity and objectively diagnosed food hypersensitivity during the first year of life. Methods A birth cohort was recruited (n = 969). At 3, 6, 9, and 12 months, information regarding feeding practices and reported symptoms of atopy were obtained. At 1 year, infants underwent a medical examination and skin prick testing to a battery of allergens. Symptomatic infants underwent food challenges. Results Adverse reactions to foods were reported by 132 (14.2%) parents at 3, 83 (9.1%) at 6, 49 (5.5%) at 9, and 65 (7.2%) at 12 months. Of the subjects, 1.0% (8/763) were sensitized to aeroallergens and 2.2% (17/763) to food allergens. Between 6 and 9 months and 9 and 12 months, 1.4% (14/969) and 2.8% (27/969) infants were diagnosed with food hypersensitivity on the basis of open food challenges and 0.9% (9/969) and 2.5% (24/969) on the basis of double-blind, placebo-controlled food challenges. Cumulative incidence of food hypersensitivity by 12 months was 4% (39/969; 95% CI, 2.9% to 5.5%) on the basis of open food challenges and 3.2% (31/969; 95% CI, 2.2% to 4.5%) on the basis of double-blind, placebo-controlled food challenges. Conclusion Between 2.2% and 5.5% of infants have food hypersensitivity in the first year of life. The rate of parental perception of food hypersensitivity is higher than the prevalence of atopic sensitization to main food allergens or objectively assessed food hypersensitivity. Clinical implications In the first year of life, the rate of parentally perceived food hypersensitivity is considerably higher than objectively assessed food hypersensitivity.
Original languageEnglish
Pages (from-to)1118-1124
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume117
Issue number5
Publication statusPublished - 3 Apr 2006

Fingerprint

Food Hypersensitivity
Incidence
Food
Infant Food
Allergens
Placebos
Cohort Studies
Parents
Parturition
Skin

Cite this

Venter, C., Pereira, B., Grundy, J. D., Clayton, C. B., Roberts, G., Higgins, B., & Dean, T. (2006). Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. Journal of Allergy and Clinical Immunology, 117(5), 1118-1124.
Venter, C. ; Pereira, B. ; Grundy, Jane D. ; Clayton, C.B. ; Roberts, G. ; Higgins, B. ; Dean, Taraneh. / Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. In: Journal of Allergy and Clinical Immunology. 2006 ; Vol. 117, No. 5. pp. 1118-1124.
@article{0734cbb3a40f47c98474a30ee02f2a7f,
title = "Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life",
abstract = "Background There are very few population-based studies investigating the incidence of food hypersensitivity during the first year of life. Objective To determine the incidence of parentally reported food hypersensitivity and objectively diagnosed food hypersensitivity during the first year of life. Methods A birth cohort was recruited (n = 969). At 3, 6, 9, and 12 months, information regarding feeding practices and reported symptoms of atopy were obtained. At 1 year, infants underwent a medical examination and skin prick testing to a battery of allergens. Symptomatic infants underwent food challenges. Results Adverse reactions to foods were reported by 132 (14.2{\%}) parents at 3, 83 (9.1{\%}) at 6, 49 (5.5{\%}) at 9, and 65 (7.2{\%}) at 12 months. Of the subjects, 1.0{\%} (8/763) were sensitized to aeroallergens and 2.2{\%} (17/763) to food allergens. Between 6 and 9 months and 9 and 12 months, 1.4{\%} (14/969) and 2.8{\%} (27/969) infants were diagnosed with food hypersensitivity on the basis of open food challenges and 0.9{\%} (9/969) and 2.5{\%} (24/969) on the basis of double-blind, placebo-controlled food challenges. Cumulative incidence of food hypersensitivity by 12 months was 4{\%} (39/969; 95{\%} CI, 2.9{\%} to 5.5{\%}) on the basis of open food challenges and 3.2{\%} (31/969; 95{\%} CI, 2.2{\%} to 4.5{\%}) on the basis of double-blind, placebo-controlled food challenges. Conclusion Between 2.2{\%} and 5.5{\%} of infants have food hypersensitivity in the first year of life. The rate of parental perception of food hypersensitivity is higher than the prevalence of atopic sensitization to main food allergens or objectively assessed food hypersensitivity. Clinical implications In the first year of life, the rate of parentally perceived food hypersensitivity is considerably higher than objectively assessed food hypersensitivity.",
author = "C. Venter and B. Pereira and Grundy, {Jane D.} and C.B. Clayton and G. Roberts and B. Higgins and Taraneh Dean",
year = "2006",
month = "4",
day = "3",
language = "English",
volume = "117",
pages = "1118--1124",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
number = "5",

}

Venter, C, Pereira, B, Grundy, JD, Clayton, CB, Roberts, G, Higgins, B & Dean, T 2006, 'Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life', Journal of Allergy and Clinical Immunology, vol. 117, no. 5, pp. 1118-1124.

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. / Venter, C.; Pereira, B.; Grundy, Jane D.; Clayton, C.B.; Roberts, G.; Higgins, B.; Dean, Taraneh.

In: Journal of Allergy and Clinical Immunology, Vol. 117, No. 5, 03.04.2006, p. 1118-1124.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life

AU - Venter, C.

AU - Pereira, B.

AU - Grundy, Jane D.

AU - Clayton, C.B.

AU - Roberts, G.

AU - Higgins, B.

AU - Dean, Taraneh

PY - 2006/4/3

Y1 - 2006/4/3

N2 - Background There are very few population-based studies investigating the incidence of food hypersensitivity during the first year of life. Objective To determine the incidence of parentally reported food hypersensitivity and objectively diagnosed food hypersensitivity during the first year of life. Methods A birth cohort was recruited (n = 969). At 3, 6, 9, and 12 months, information regarding feeding practices and reported symptoms of atopy were obtained. At 1 year, infants underwent a medical examination and skin prick testing to a battery of allergens. Symptomatic infants underwent food challenges. Results Adverse reactions to foods were reported by 132 (14.2%) parents at 3, 83 (9.1%) at 6, 49 (5.5%) at 9, and 65 (7.2%) at 12 months. Of the subjects, 1.0% (8/763) were sensitized to aeroallergens and 2.2% (17/763) to food allergens. Between 6 and 9 months and 9 and 12 months, 1.4% (14/969) and 2.8% (27/969) infants were diagnosed with food hypersensitivity on the basis of open food challenges and 0.9% (9/969) and 2.5% (24/969) on the basis of double-blind, placebo-controlled food challenges. Cumulative incidence of food hypersensitivity by 12 months was 4% (39/969; 95% CI, 2.9% to 5.5%) on the basis of open food challenges and 3.2% (31/969; 95% CI, 2.2% to 4.5%) on the basis of double-blind, placebo-controlled food challenges. Conclusion Between 2.2% and 5.5% of infants have food hypersensitivity in the first year of life. The rate of parental perception of food hypersensitivity is higher than the prevalence of atopic sensitization to main food allergens or objectively assessed food hypersensitivity. Clinical implications In the first year of life, the rate of parentally perceived food hypersensitivity is considerably higher than objectively assessed food hypersensitivity.

AB - Background There are very few population-based studies investigating the incidence of food hypersensitivity during the first year of life. Objective To determine the incidence of parentally reported food hypersensitivity and objectively diagnosed food hypersensitivity during the first year of life. Methods A birth cohort was recruited (n = 969). At 3, 6, 9, and 12 months, information regarding feeding practices and reported symptoms of atopy were obtained. At 1 year, infants underwent a medical examination and skin prick testing to a battery of allergens. Symptomatic infants underwent food challenges. Results Adverse reactions to foods were reported by 132 (14.2%) parents at 3, 83 (9.1%) at 6, 49 (5.5%) at 9, and 65 (7.2%) at 12 months. Of the subjects, 1.0% (8/763) were sensitized to aeroallergens and 2.2% (17/763) to food allergens. Between 6 and 9 months and 9 and 12 months, 1.4% (14/969) and 2.8% (27/969) infants were diagnosed with food hypersensitivity on the basis of open food challenges and 0.9% (9/969) and 2.5% (24/969) on the basis of double-blind, placebo-controlled food challenges. Cumulative incidence of food hypersensitivity by 12 months was 4% (39/969; 95% CI, 2.9% to 5.5%) on the basis of open food challenges and 3.2% (31/969; 95% CI, 2.2% to 4.5%) on the basis of double-blind, placebo-controlled food challenges. Conclusion Between 2.2% and 5.5% of infants have food hypersensitivity in the first year of life. The rate of parental perception of food hypersensitivity is higher than the prevalence of atopic sensitization to main food allergens or objectively assessed food hypersensitivity. Clinical implications In the first year of life, the rate of parentally perceived food hypersensitivity is considerably higher than objectively assessed food hypersensitivity.

M3 - Article

VL - 117

SP - 1118

EP - 1124

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -

Venter C, Pereira B, Grundy JD, Clayton CB, Roberts G, Higgins B et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. Journal of Allergy and Clinical Immunology. 2006 Apr 3;117(5):1118-1124.