Ground-Breaking Changes in Mimetic and Novel Nanostructured Composites for Intelligent-, Adaptive-and In vivo-Responsive Drug Delivery Therapies

A series of strategies are currently proposed for more effective prophylactic therapy of acute and chronic ailments and palliative medicinal care. These resilient illnesses include cancers, tissue degeneration (e.g., macular, mesenchymal, vascular, epithelial, hemopoietal and parenchymal cells), immune system failure, systemic infections and neurological conditions. Treatments use solid drug and porous drug implants, gel, liquid (semisolids) and solid dosages and drug-bearing tissue mimetics. Such mimetics may be used after surgical intervention. The platform technologies, "molecular sculpture" and application chemistry use various polymer (natural, chemically modified and biocompatible novel/synthetic) and amphiphile self-assembly forms for a visionary nanofabrication, and surface or bulk nanoengineering-or nanolithographic-type patterning of nanomedicines. Smart methodologies of this type are frequently stimuliresponsive (e.g., redox state, enzyme, cation and pH), and use biodegradable materials. Some difficulties with biocompatibility and toxicology are, and continue to be, omnipresent.