Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study

Jingmin Zhu; Jiana Li; Emma Chapman; Huahong Shi; Corina Ciocan; Kai Chen; Xiaodong Shi; JunLiang Zhou; Peiying Sun; Yueyao Zheng; Jeanette Rotchell

doi:10.1007/s00128-022-03461-2

Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study

Jingmin Zhu, Jiana Li, Emma Chapman, Huahong Shi, Corina Ciocan, Kai Chen, Xiaodong Shi, JunLiang Zhou, Peiying Sun, Yueyao Zheng, Jeanette Rotchell

School of Applied Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

This preliminary survey analysed mussel atresia incidences, estrogen-responsive and apoptotic-specific molecular end points, and aqueous and gonadal levels of selected estrogens from the East China coast. Estrogen levels were low (e.g. < LOD-28.36 ng/L, < LOD-3.88 ng/g wet weight of tissue for BPA) relative to worldwide freshwater environments, but high oocyte follicle atresia incidences (up to 26.6%) occurred at selected sites. Expression of estrogen-responsive ER2 was significantly increased in males relative to females at sites with high atresia incidences in females. A second estrogen-responsive gene, V9, was significantly increased at two sites in April in females relative to males; the opposite was true for the remaining two sites. Apoptosis-specific genes (Bcl-2, fas) showed elevated expression in males relative to females at the site with the highest atresia incidence. These results provide coastal estrogen levels and the utility of several estrogen-specific molecular-level markers for marine mussels.

Original language	English
Pages (from-to)	1111-1117
Number of pages	7
Journal	Bulletin of Environmental Contamination and Toxicology
Volume	108
Issue number	6
DOIs	https://doi.org/10.1007/s00128-022-03461-2
Publication status	Published - 24 Jan 2022

Bibliographical note

Funding Information:
The work funded by the State Key Laboratory of Estuarine and Coastal Research Open Research Fund (SKLEC-KF201405) and the Chinese Government High-End Foreign Experts Fund to JR, and grants from National Natural Science Foundation of China (41171376 and 41571467).

Publisher Copyright:
© 2022, The Author(s).

Keywords

Apoptosis
Article
Atresia
Estrogen
Mytilus

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Zhu, J., Li, J., Chapman, E., Shi, H., Ciocan, C., Chen, K., Shi, X., Zhou, J., Sun, P., Zheng, Y., & Rotchell, J. (2022). Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study. Bulletin of Environmental Contamination and Toxicology, 108(6), 1111-1117. https://doi.org/10.1007/s00128-022-03461-2

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title = "Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study",

abstract = "This preliminary survey analysed mussel atresia incidences, estrogen-responsive and apoptotic-specific molecular end points, and aqueous and gonadal levels of selected estrogens from the East China coast. Estrogen levels were low (e.g. < LOD-28.36 ng/L, < LOD-3.88 ng/g wet weight of tissue for BPA) relative to worldwide freshwater environments, but high oocyte follicle atresia incidences (up to 26.6%) occurred at selected sites. Expression of estrogen-responsive ER2 was significantly increased in males relative to females at sites with high atresia incidences in females. A second estrogen-responsive gene, V9, was significantly increased at two sites in April in females relative to males; the opposite was true for the remaining two sites. Apoptosis-specific genes (Bcl-2, fas) showed elevated expression in males relative to females at the site with the highest atresia incidence. These results provide coastal estrogen levels and the utility of several estrogen-specific molecular-level markers for marine mussels.",

keywords = "Apoptosis, Article, Atresia, Estrogen, Mytilus",

author = "Jingmin Zhu and Jiana Li and Emma Chapman and Huahong Shi and Corina Ciocan and Kai Chen and Xiaodong Shi and JunLiang Zhou and Peiying Sun and Yueyao Zheng and Jeanette Rotchell",

note = "Funding Information: The work funded by the State Key Laboratory of Estuarine and Coastal Research Open Research Fund (SKLEC-KF201405) and the Chinese Government High-End Foreign Experts Fund to JR, and grants from National Natural Science Foundation of China (41171376 and 41571467). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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Zhu, J, Li, J, Chapman, E, Shi, H, Ciocan, C, Chen, K, Shi, X, Zhou, J, Sun, P, Zheng, Y & Rotchell, J 2022, 'Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study', Bulletin of Environmental Contamination and Toxicology, vol. 108, no. 6, pp. 1111-1117. https://doi.org/10.1007/s00128-022-03461-2

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T1 - Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study

AU - Zhu, Jingmin

AU - Li, Jiana

AU - Chapman, Emma

AU - Shi, Huahong

AU - Ciocan, Corina

AU - Chen, Kai

AU - Shi, Xiaodong

AU - Zhou, JunLiang

AU - Sun, Peiying

AU - Zheng, Yueyao

AU - Rotchell, Jeanette

N1 - Funding Information: The work funded by the State Key Laboratory of Estuarine and Coastal Research Open Research Fund (SKLEC-KF201405) and the Chinese Government High-End Foreign Experts Fund to JR, and grants from National Natural Science Foundation of China (41171376 and 41571467). Publisher Copyright: © 2022, The Author(s).

PY - 2022/1/24

Y1 - 2022/1/24

N2 - This preliminary survey analysed mussel atresia incidences, estrogen-responsive and apoptotic-specific molecular end points, and aqueous and gonadal levels of selected estrogens from the East China coast. Estrogen levels were low (e.g. < LOD-28.36 ng/L, < LOD-3.88 ng/g wet weight of tissue for BPA) relative to worldwide freshwater environments, but high oocyte follicle atresia incidences (up to 26.6%) occurred at selected sites. Expression of estrogen-responsive ER2 was significantly increased in males relative to females at sites with high atresia incidences in females. A second estrogen-responsive gene, V9, was significantly increased at two sites in April in females relative to males; the opposite was true for the remaining two sites. Apoptosis-specific genes (Bcl-2, fas) showed elevated expression in males relative to females at the site with the highest atresia incidence. These results provide coastal estrogen levels and the utility of several estrogen-specific molecular-level markers for marine mussels.

AB - This preliminary survey analysed mussel atresia incidences, estrogen-responsive and apoptotic-specific molecular end points, and aqueous and gonadal levels of selected estrogens from the East China coast. Estrogen levels were low (e.g. < LOD-28.36 ng/L, < LOD-3.88 ng/g wet weight of tissue for BPA) relative to worldwide freshwater environments, but high oocyte follicle atresia incidences (up to 26.6%) occurred at selected sites. Expression of estrogen-responsive ER2 was significantly increased in males relative to females at sites with high atresia incidences in females. A second estrogen-responsive gene, V9, was significantly increased at two sites in April in females relative to males; the opposite was true for the remaining two sites. Apoptosis-specific genes (Bcl-2, fas) showed elevated expression in males relative to females at the site with the highest atresia incidence. These results provide coastal estrogen levels and the utility of several estrogen-specific molecular-level markers for marine mussels.

KW - Apoptosis

KW - Article

KW - Atresia

KW - Estrogen

KW - Mytilus

U2 - 10.1007/s00128-022-03461-2

DO - 10.1007/s00128-022-03461-2

M3 - Article

SN - 0007-4861

VL - 108

SP - 1111

EP - 1117

JO - Bulletin of Environmental Contamination and Toxicology

JF - Bulletin of Environmental Contamination and Toxicology

IS - 6

ER -

Gonadal Atresia, Estrogen-Responsive, and Apoptosis-Specific mRNA Expression in Marine Mussels from the East China Coast: A Preliminary Study

Abstract

Bibliographical note

Keywords

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