Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging

Sreejith Raveendran, Hoong Ta Lim, Toru Maekawa, Murukeshan Vadakke Matham, D. Sakthi Kumar

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Bioinert gold nanoparticles of various shapes and functionalities are widely accepted as contrast agents (CAs) for several modalities of imaging, viz., electron microscopy, computerized tomography (CT), X-ray and photoacoustic (PA) imaging. However, testing of novel compact-imaging probes for ocular diagnostic imaging is always challenging. Here, ultra-fast microwave oven synthesized gold nanocages (AuNcgs) were successfully demonstrated for high- contrast PA ocular imaging for the first time. Methods are described for the synthesis, characterization and application of quickly synthesized AuNcgs in diagnostic ocular imaging. PA and ultrasound (US) images were acquired using a commercial US imaging scanner integrated with a tunable nanosecond pulsed laser. This integrated hybrid-modality system is a combined PA and US platform for imaging which enabled acquiring of complementary structural and optical absorption-based information simultaneously. Initial experiments were conducted using tubings filled with solutions of different concentrations of quickly synthesized AuNcgs. Biological PA and US imagings were demonstrated using enucleated porcine eye samples. Based on the acquired results, it is envisaged that AuNcgs can be employed as a high strength PA CA to potentially diagnose ocular disease like uveal melanoma in the near future.

Original languageEnglish
Pages (from-to)13959-13968
Number of pages10
JournalNanoscale
Volume10
Issue number29
DOIs
Publication statusPublished - 7 Aug 2018

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Photoacoustic effect
Gold
Imaging techniques
Ultrasonics
Contrast Media
Microwave ovens
Computerized tomography
Tubing
Hybrid systems
Pulsed lasers
Light absorption
Electron microscopy
Nanoparticles
X rays
Testing

Cite this

Raveendran, S., Lim, H. T., Maekawa, T., Vadakke Matham, M., & Sakthi Kumar, D. (2018). Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging. 10(29), 13959-13968. https://doi.org/10.1039/c8nr02866d
Raveendran, Sreejith ; Lim, Hoong Ta ; Maekawa, Toru ; Vadakke Matham, Murukeshan ; Sakthi Kumar, D. / Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging. 2018 ; Vol. 10, No. 29. pp. 13959-13968.
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Raveendran, S, Lim, HT, Maekawa, T, Vadakke Matham, M & Sakthi Kumar, D 2018, 'Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging' vol. 10, no. 29, pp. 13959-13968. https://doi.org/10.1039/c8nr02866d

Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging. / Raveendran, Sreejith; Lim, Hoong Ta; Maekawa, Toru; Vadakke Matham, Murukeshan; Sakthi Kumar, D.

Vol. 10, No. 29, 07.08.2018, p. 13959-13968.

Research output: Contribution to journalArticleResearchpeer-review

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Raveendran S, Lim HT, Maekawa T, Vadakke Matham M, Sakthi Kumar D. Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging. 2018 Aug 7;10(29):13959-13968. https://doi.org/10.1039/c8nr02866d