Gene Birth, Death, Modification, Poaching, Crippling, Dimorphism and Culling: The Challenge for Genomics

Lindsay G. Cowell, N.A. Mitchison, Nadia Terrazzini, Brigitte Muller, Laurie G. Smith

Research output: Contribution to journalArticle

Abstract

This brief survey covers the main events in the evolution of eukaryotic genes in broad brush style. It concentrates on regulatory DNA, an area that has been relatively neglected, and where we believe that the present case-by-case analysis is likely to be supplemented by more general, genomics-based methods. It is biased towards immunology, in part because the immune system relies heavily on polymorphism of regulatory DNA to provide flexibility and in part because of our own field of interest. It gives a central place to recent work that has shown how analysis of electronic genomes can be used to trace gene duplication and its consequences. It mentions cellular systems that offer models for the study of evolution of regulatory DNA on a small scale. It alludes to the unanswered question of how genomes adjust their overall size
Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalProceedings of the Indian National Science Academy
Volume69
Issue number4
Publication statusPublished - 1 Jan 2003

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