Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Thanh H. Nguyen, Charlotte M. Thomas, David Timson, Mark J. Van Raaij

Research output: Contribution to journalArticle

Abstract

The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain).
Original languageEnglish
Pages (from-to)2879-2886
Number of pages8
JournalParasitology Research
Volume115
Issue number7
DOIs
Publication statusPublished - 16 Apr 2016

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Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s00436-016-5046-x

Keywords

  • Liver fluke
  • Calcium-binding protein
  • Dynein light chain
  • Crystal structure
  • Helminth protein

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