Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Thanh H. Nguyen; Charlotte M. Thomas; David Timson; Mark J. Van Raaij

doi:10.1007/s00436-016-5046-x

Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Thanh H. Nguyen, Charlotte M. Thomas, David Timson, Mark J. Van Raaij

University of Brighton

Research output: Contribution to journal › Article › peer-review

Abstract

The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain).

Original language	English
Pages (from-to)	2879-2886
Number of pages	8
Journal	Parasitology Research
Volume	115
Issue number	7
DOIs	https://doi.org/10.1007/s00436-016-5046-x
Publication status	Published - 16 Apr 2016

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s00436-016-5046-x

Keywords

Liver fluke
Calcium-binding protein
Dynein light chain
Crystal structure
Helminth protein

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title = "Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain",

abstract = "The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain).",

keywords = "Liver fluke, Calcium-binding protein, Dynein light chain, Crystal structure, Helminth protein",

author = "Nguyen, {Thanh H.} and Thomas, {Charlotte M.} and David Timson and {Van Raaij}, {Mark J.}",

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doi = "10.1007/s00436-016-5046-x",

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T1 - Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

AU - Nguyen, Thanh H.

AU - Thomas, Charlotte M.

AU - Timson, David

AU - Van Raaij, Mark J.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s00436-016-5046-x

PY - 2016/4/16

Y1 - 2016/4/16

N2 - The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain).

AB - The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain).

KW - Liver fluke

KW - Calcium-binding protein

KW - Dynein light chain

KW - Crystal structure

KW - Helminth protein

U2 - 10.1007/s00436-016-5046-x

DO - 10.1007/s00436-016-5046-x

M3 - Article

SN - 0932-0113

VL - 115

SP - 2879

EP - 2886

JO - Parasitology Research

JF - Parasitology Research

IS - 7

ER -

Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Abstract

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Keywords

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