The common liver fluke Fasciola hepatica causes an increasing burden on human and animal health, partly because of the spread of drug-resistant isolates. As a consequence, there is considerable interest in developing new drugs to combat liver fluke infections. A group of potential targets is a family of calcium-binding proteins which combine an N-terminal domain with two EF-hand motifs and a C-terminal domain with predicted similarity to dynein light chains (DLC-like domain).
Bibliographical noteThe final publication is available at Springer via http://dx.doi.org/10.1007/s00436-016-5046-x
- Liver fluke
- Calcium-binding protein
- Dynein light chain
- Crystal structure
- Helminth protein
Nguyen, T. H., Thomas, C. M., Timson, D., & Van Raaij, M. J. (2016). Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain. Parasitology Research, 115(7), 2879-2886. https://doi.org/10.1007/s00436-016-5046-x