A growing body of literature suggests pharmaceutical contamination poses an increasing risk to marine ecosystems. Paracetamol or acetaminophen is the most widely used medicine in the world and has recently been detected in seawater. Here we present the results of a short exposure of blue mussel adults to 40 ng/L, 250 ng/L and 100 µg/L of paracetamol. Three potential targets, estrogen receptor 2 (ER2), vitelline envelope zona pellucida domain 9 (V9), and vitellogenin (VTG) were selected to assess the endocrine disrupting response. The results indicate that short exposure to paracetamol downregulates the mRNA expression of all three genes. Different patterns of dowregulation were identified: VTG expression was markedly lower in all exposed mussels, irrespective of paracetamol concentration; whereas the responses of ER2 and V9 suggested concentration-dependent trends. In conclusion, paracetamol has the potential to alter the regulation of genes related to reproduction.
|Publication status||Published - 16 Sep 2019|
|Event||SETAC Cartagena – SETAC Latin America 13th Biennial Meeting - Cartagena, Cartagena, Colombia|
Duration: 15 Sep 2019 → 18 Sep 2019
|Conference||SETAC Cartagena – SETAC Latin America 13th Biennial Meeting|
|Period||15/09/19 → 18/09/19|