Evaluation of Reproduction-Related Genes as Possible Targets of Paracetamol in the Blue Mussel, Mytilus edulis

Research output: Contribution to conferenceAbstract

Abstract

A growing body of literature suggests pharmaceutical contamination poses an increasing risk to marine ecosystems. Paracetamol or acetaminophen is the most widely used medicine in the world and has recently been detected in seawater. Here we present the results of a short exposure of blue mussel adults to 40 ng/L, 250 ng/L and 100 µg/L of paracetamol. Three potential targets, estrogen receptor 2 (ER2), vitelline envelope zona pellucida domain 9 (V9), and vitellogenin (VTG) were selected to assess the endocrine disrupting response. The results indicate that short exposure to paracetamol downregulates the mRNA expression of all three genes. Different patterns of dowregulation were identified: VTG expression was markedly lower in all exposed mussels, irrespective of paracetamol concentration; whereas the responses of ER2 and V9 suggested concentration-dependent trends. In conclusion, paracetamol has the potential to alter the regulation of genes related to reproduction.
Original languageEnglish
Publication statusPublished - 16 Sep 2019
EventSETAC Cartagena – SETAC Latin America 13th Biennial Meeting - Cartagena, Cartagena, Colombia
Duration: 15 Sep 201918 Sep 2019
https://sla2019.setac.org/

Conference

ConferenceSETAC Cartagena – SETAC Latin America 13th Biennial Meeting
CountryColombia
CityCartagena
Period15/09/1918/09/19
Internet address

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